CELL-SURFACE PROTEINS REACTING WITH ACTIVATED COMPLEMENT COMPONENTS
CELL-SURFACE PROTEINS REACTING WITH ACTIVATED COMPLEMENT COMPONENTS
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DOI：
10.1159/000463091
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发表时间：
1989-05-01
期刊：
影响因子：
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通讯作者：
LAMBRIS, JD
中科院分区：
文献类型：
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作者：
BECHERER, JD;ALSENZ, J;LAMBRIS, JD
补体活化产物介导的生物活性包括细胞、细菌和病毒的溶解、炎症、吞噬和免疫调节。这些反应是通过几种补体蛋白的激活形式与细胞膜蛋白相互作用而实现的。本报告综述了各种补体受体的结构、配体特异性和功能，特别是那些与C3激活片段结合的受体。此外，我们还简要总结了与C3结合的外来颗粒上的表面蛋白及其在这些生物发病机制中的可能作用。
The biologic activities mediated by the products of complement activation include cellular, bacterial, and viral lysis, inflammation, phagocytosis, and immunoregula- tion. These responses are achieved through the interaction of the activated forms of several of the complement proteins with cell membrane proteins. This report reviews aspects of the structure, ligand specificity, and function of the various complement receptors with particular emphasis on those receptors which bind to the activated fragments of C3. In addition, we briefly summarize the surface proteins on foreign particles that bind C3 and their possible role in the pathogenesis of these organisms.