Neuronal synchrony during anesthesia: A thalamocortical model
Neuronal synchrony during anesthesia: A thalamocortical model
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DOI：
10.1529/biophysj.108.134635
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发表时间：
2008-09-15
影响因子：
3.4
通讯作者：
McClintock, Peter V. E.
中科院分区：
文献类型：
--
作者：
Sheeba, Jane H.;Stefanovska, Aneta;McClintock, Peter V. E.
越来越多的证据支持时间编码假说，即神经元放电的时间相关性可能有助于将分布的神经元活动绑定到独特的表征中，特别是theta （3.5-7.5 Hz）和delta （0.5 < 3.5 Hz）振荡有助于信息编码。θ和δ节律参与了不同的睡眠阶段，在麻醉期间，它们会随着麻醉的深度而发生变化。我们引入了一个相互作用的神经元集合的丘脑皮质模型来描述theta和delta振荡之间的相位关系，特别是在深度和轻度麻醉期间。考虑到丘脑皮质神经元振荡器之间的不对称和远距离相互作用。模型结果与实验结果进行了比较。delta和theta活动被发现是分别产生的，分别由丘脑和皮层控制。神经束内和神经束间同步程度的变化表明，神经束在深度麻醉时抑制信息编码，而在轻度麻醉时促进信息编码。
There is growing evidence in favor of the temporal-coding hypothesis that temporal correlation of neuronal discharges may serve to bind distributed neuronal activity into unique representations and, in particular, that theta (3.5-7.5 Hz) and delta (0.5 < 3.5 Hz) oscillations facilitate information coding. The theta-and delta-rhythms are shown to be involved in various sleep stages, and during anesthesia, they undergo changes with the depth of anesthesia. We introduce a thalamocortical model of interacting neuronal ensembles to describe phase relationships between theta-and delta-oscillations, especially during deep and light anesthesia. Asymmetric and long-range interactions among the thalamocortical neuronal oscillators are taken into account. The model results are compared with experimental observations. The delta-and theta-activities are found to be separately generated and are governed by the thalamus and cortex, respectively. Changes in the degree of intraensemble and interensemble synchrony imply that the neuronal ensembles inhibit information coding during deep anesthesia and facilitate it during light anesthesia.