Low calcium intake is associated with increased bone resorption in postmenopausal Japanese women: Yokogoshi Study
Low calcium intake is associated with increased bone resorption in postmenopausal Japanese women: Yokogoshi Study
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DOI：
10.1017/s1368980009005084
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发表时间：
2009-12-01
影响因子：
3.2
通讯作者：
Yamamoto, Masaharu
中科院分区：
文献类型：
--
作者：
Nakamura, Kazutoshi;Saito, Toshiko;Yamamoto, Masaharu
目的：低钙摄入在日本女性中很常见，但其对骨代谢的影响尚未完全阐明。本研究的目的是确定绝经后日本妇女钙摄入量与血清骨转换指标之间的关系。设计：横断面研究。背景：社区环境。研究对象：595名居住在家中的绝经后日本妇女。CA摄入量由FFQ评估，血清I型胶原交联型N-端肽(NTX)和骨钙素作为骨转换的标志物。结果：受试者平均年龄64.5岁(SD5.8岁)，平均钙摄入量为527(SD160)mg/d，CA摄入量与血清Ntx显著相关(P=0.0104)，与血清骨钙素无关。钙摄入量最低四分位数的平均血清NTX浓度(
Objective: Low Ca intake is common among Japanese women, but its effect Oil bone metabolism has not been fully elucidated. The aim Of the present study was to determine the relationship between Ca intake and serum markers of bone turnover ill postmenopausal Japanese women.Design: A cross-sectional study.Setting: A community setting.Subjects: Subjects were 595 home-dwelling postmenopausal Japanese women. Ca intake was assessed by a validated FFQ, Serum type I collagen cross-linked N-telopeptides (NTX) and osteocalcin Were measured as markers of bone turnover. The relationships between demographic characteristics, lifestyles, serum Ca, vitamin D and intact serum parathyroid hormone and bone turnover were also assessed.Results: The average age of the subjects was 64.5 (SD 5.8) years and the mean Ca intake was 527 (SD 160) mg/d. Ca intake was significantly associated with serum NTX (P=0.0104); but not with serum osteocalcin. Mean serum NTX concentration in the lowest quartile of Ca intake (