Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats.
Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats.
复制标题
甘草酸减轻博莱霉素诱导的大鼠肺纤维化
DOI：
10.3389/fphar.2015.00215
复制
发表时间：
2015
影响因子：
5.6
通讯作者：
Wu T
中科院分区：
文献类型：
--
作者：
Gao L;Tang H;He H;Liu J;Mao J;Ji H;Lin H;Wu T
特发性肺纤维化是一种进行性和致死性肺间质性疾病，目前缺乏有效的治疗方法。甘草酸（Glycyrrhizic acid， GA）是一种从传统中草药甘草中提取的天然化合物，最近有报道称其在动物模型中对肺损伤和肝纤维化有改善作用，但GA是否对肺纤维化有治疗作用尚不清楚。在这项研究中，我们研究了GA对博来霉素（BLM）诱导的肺纤维化大鼠模型肺纤维化的潜在治疗作用。结果表明，GA治疗显著改善了blm诱导的肺纤维化，减轻了blm诱导的炎症、氧化应激、上皮-间质转化和肺部转化生长因子- β信号通路的激活。此外，我们在体外证明了GA处理抑制3T6成纤维细胞的增殖，诱导细胞周期阻滞并促进细胞凋亡，这意味着GA介导的纤维增殖抑制可能有助于抗blm诱导的肺纤维化。总之，我们的研究表明GA在治疗肺纤维化方面具有治疗潜力。
Idiopathic pulmonary fibrosis is a progressive and lethal form of interstitial lung disease that lacks effective therapies at present. Glycyrrhizic acid (GA), a natural compound extracted from a traditional Chinese herbal medicine Glycyrrhiza glabra, was recently reported to benefit lung injury and liver fibrosis in animal models, yet whether GA has a therapeutic effect on pulmonary fibrosis is unknown. In this study, we investigated the potential therapeutic effect of GA on pulmonary fibrosis in a rat model with bleomycin (BLM)-induced pulmonary fibrosis. The results indicated that GA treatment remarkably ameliorated BLM-induced pulmonary fibrosis and attenuated BLM-induced inflammation, oxidative stress, epithelial-mesenchymal transition, and activation of transforming growth factor-beta signaling pathway in the lungs. Further, we demonstrated that GA treatment inhibited proliferation of 3T6 fibroblast cells, induced cell cycle arrest and promoted apoptosis in vitro, implying that GA-mediated suppression of fibroproliferation may contribute to the anti-fibrotic effect against BLM-induced pulmonary fibrosis. In summary, our study suggests a therapeutic potential of GA in the treatment of pulmonary fibrosis.