Convergent intron loss of MRP1 in Drosophila and mosquito species.
Convergent intron loss of MRP1 in Drosophila and mosquito species.
复制标题
果蝇和蚊子中 MRP1 的会聚内含子丢失。
DOI：
10.1093/jhered/esr095
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Q. Zeng
中科院分区：
文献类型：
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作者：
Lei;Zhen Ding;Y. Qian;Q. Zeng
先前的研究发现，果蝇的MRP1基因同源物DMRP1/CG6214在编码区含有12个外显子。在本研究中，我们比较了黑腹果蝇和雄果蝇的DMRP1/CG6214基因，结果表明雄果蝇在2号外显子上有一个额外的内含子，这意味着内含子的丢失或获得可能发生在这个位点。为了追踪内含子（内含子Z）的进化，我们克隆或注释了37种节肢动物的同源核苷酸序列。系统发育分析表明，内含子Z存在于节肢动物共同祖先中，时间超过420 Ma。此外，我们发现苦参亚属种和蚊子（库蚊）独立丢失内含子Z，并表现出进化趋同。
Previous study revealed that the MRP1 gene ortholog DMRP1/CG6214 of Drosophila melanogaster contains 12 exons in the coding region. In the current study, the genes of DMRP1/CG6214 from D. melanogaster and Drosophila virilis were compared, and the result indicated that D. virilis had an extra intron located in exon 2, implying that intron loss or gain might have occurred at this locus. To track the evolution of the extra intron (Intron Z), orthologous nucleotide sequences of 37 arthropod species were cloned or annotated. Based on phylogenetic analysis, we found that Intron Z should present in the common ancestor of arthropod species, more than 420 Ma. In addition, we found that Sophophora subgenus species and mosquito (Culex pipiens) lost Intron Z independently, showing evolutionary convergence.
影响因子：
7
作者：
Carmel, Liran;Wolf, Yuri I.;Koonin, Eugene V.
通讯作者：
Koonin, Eugene V.
影响因子：
7
作者：
Kent, WJ;Zahler, AM
通讯作者：
Zahler, AM
自适应分子趋同：分子进化与分子系统发育。
影响因子：
--
作者：
Castoe,ToddA;deKoning,APJason;Pollock,DavidD
通讯作者：
Pollock,DavidD