DNA PLOIDY AND SURVIVAL IN BREAST-CANCER PATIENTS
DNA PLOIDY AND SURVIVAL IN BREAST-CANCER PATIENTS
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DOI：
10.1002/cyto.990080217
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发表时间：
1987-03-01
期刊：
影响因子：
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通讯作者：
HERMANS, J
中科院分区：
文献类型：
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作者：
CORNELISSE, CJ;VANDEVELDE, CJH;HERMANS, J
应用冷冻或脱蜡肿瘤标本对1975-1984年间接受治疗的565例原发性乳腺癌患者进行了流式细胞术DNA倍体测量。29%的病例为二倍体，61%为单一非整倍体干细胞系，10%为多倍体。非整倍体肿瘤雌激素受体阴性率高于二倍体肿瘤，但倍体类型与TNM分期无明显相关性。腋窝淋巴结阳性超过10个的患者主要为非整倍体肿瘤。二倍体肿瘤和低非整倍体肿瘤患者的总体和远端无复发生存率较高。根据淋巴结受累程度、TNM分期和绝经期对患者进行分层，结果显示非整倍体的预后影响主要在局部晚期疾病患者中明显。绝经后淋巴结阳性的二倍体肿瘤患者的预后明显好于非整倍体肿瘤患者，但在绝经前组中没有发现这种差异。多变量分析与考克斯比例风险模型表明，倍性是一个额外的，独立的预后因素绝经后患者。
Flow cytometric DNA ploidy measurements using frozen or deparaffinized tumor specimens were performed on 565 primary breast cancers from patients treated in the period 1975-1984. Twenty-nine percent of the cases were diploid, 61% had a single aneuploid stemline, and 10% were multiploid. Aneuploid tumors more often had negative estrogen receptor values than diploid tumors, but no significant correlation was found between ploidy class and TNM stage. Patients with more than ten positive axillary lymph nodes had predominantly aneuploid tumors. Overall and distant relapse-free survival were higher for patients with diploid tumors and low-aneuploid tumors. Stratification of the patients according to degee of lymph node involvement, TNM stage, and menopausal stage showed that the prognostic effect of aneuploidy was apparent predominantly in patients with locally advanced disease. Postmenopausal node-positive patients with diploid tumors had a significantly better prognosis than those with aneuploid tumors, but this difference was not found for the comparable premenopausal group. Multivariate analysis with the Cox proportional hazards model indicated that ploidy is an additional, independent prognostic factor in postmenopausal patients.