Vitronectin improves cell survival after radiation injury in human umbilical vein endothelial cells.
Vitronectin improves cell survival after radiation injury in human umbilical vein endothelial cells.
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DOI：
10.1016/j.fob.2012.10.002
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发表时间：
2012
期刊：
影响因子：
2.6
通讯作者：
Tajima K
中科院分区：
文献类型：
--
作者：
Hazawa M;Yasuda T;Noshiro K;Saotome-Nakamura A;Fukuzaki T;Michikawa Y;Gotoh T;Tajima K
玻连蛋白（Vitronectin，VN）是一种多功能蛋白，通过细胞表面的整合素受体参与细胞外基质（extracellular matrix，ECM）与细胞的结合，是维持生物体内平衡的重要环境过程。我们研究了VN如何影响辐射损伤后内皮细胞的存活。VN通过调节GSK-3β的活性，减弱辐射诱导的细胞周期进程抑制剂p21的表达，并选择性地抑制辐射暴露后Erk和p38 MAPK依赖的p21诱导。VN还减少了caspase-3的裂解，从而抑制辐射诱导的凋亡性细胞死亡。这些结果表明，VN在辐射损伤后的细胞存活中具有重要作用。③ Vitronectin可防止辐射损伤后内皮细胞的凋亡。用vibronectin处理内皮细胞可消除G1期阻滞。Vitronectin通过阻断ERK和p38 MAPK途径抑制p21表达。Vibronectin可抑制辐射诱导的GSK-3β失活。
Vitronectin (VN) is a multi-functional protein involved in extracellular matrix (ECM)-cell binding through integrin receptors on the cell surface, which is an important environmental process for maintaining biological homeostasis. We investigated how VN affects the survival of endothelial cells after radiation damage. VN attenuated radiation-induced expression of p21, an inhibitor of cell cycle progression, and selectively inhibited Erk- and p38 MAPK-dependent p21 induction after radiation exposure through regulation of the activity of GSK-3β. VN also reduced the cleavage of caspase-3, thereby inhibiting radiation-induced apoptotic cell death. These results suggest that VN has important roles in cell survival after radiation damage. ▸ Vitronectin prevented apoptosis of endothelial cells after radiation damage. ▸ Treatment of endothelial cells with vibronectin abrogated G1 arrest. ▸ Vitronectin inhibited p21 expression through prevention of ERK and p38 MAPK pathways. ▸ Radiation-induced inactivation of GSK-3β was suppressed by vibronectin.
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