Aspergillus fumigatus cell wall components differentially modulate host TLR2 and TLR4 responses
Aspergillus fumigatus cell wall components differentially modulate host TLR2 and TLR4 responses
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DOI：
10.1016/j.micinf.2010.10.005
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发表时间：
2011-02-01
影响因子：
5.8
通讯作者：
Netea, Mihai G.
中科院分区：
文献类型：
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作者：
Chai, Louis Y. A.;Vonk, Alieke G.;Netea, Mihai G.
烟曲霉分生孢子通过调节Toll样受体(TLR)2和TLR4信号来减轻宿主的促炎反应，但介导这一效应的确切机制尚不清楚。在目前的研究中，曲霉细胞壁多糖成分在调节宿主启动促炎反应的能力方面的作用被研究。曲霉细胞壁组分及其主要成分在调节宿主TLR介导的白介素6产生方面表现出不同的能力。β-葡聚糖特异性地抑制TLR4诱导的反应，而α-葡聚糖抑制TLR2-和TLR4-刺激诱导的IL-6。半乳甘露聚糖可减弱TLR4介导的反应，但对TLR2信号转导的抑制作用有限。另一方面，甲壳素没有显著的免疫调节能力。真菌细胞壁改变病原体免疫信号的能力可能与其毒力和合并感染的发病机制有关。(C)2010年巴斯德研究所。爱思唯尔·马森公司出版。版权所有。
Aspergillus fumigatus conidia attenuates host proinflammatory responses through modulation of Toll-like receptor (TLR)2 and TLR4 signaling, but file precise mechanisms that mediate this effect are not known. In the present study, the role of the Aspergillus cell wall polysaccharide constituents responsible for the modulation of host capability to mount a proinflammatory response was studied. Aspergillus cell wall fractions and its major components showed differential capabilities in modulating host TLR-mediated interleukin (IL)-6 production. Beta-glucan specifically suppressed TLR4-induced response, while alpha-glucan inhibited IL-6 induced through TLR2- and TLR4-stimulation. Galactomannan diminished TLR4-mediated response, while its inhibitory effects on TLR2-signaling were limited. Chitin, on the other hand, did not have significant immunomodulatory capability. The ability of the fungal cell wall to alter the immune signature of the pathogen may contribute to its virulence and the pathogenesis of co-infection. (C) 2010 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.