Allele-sharing models: LOD scores and accurate linkage tests
Allele-sharing models: LOD scores and accurate linkage tests
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DOI：
10.1086/301592
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发表时间：
1997-11-01
影响因子：
9.8
通讯作者：
Cox, NJ
中科院分区：
文献类型：
--
作者：
Kong, A;Cox, NJ
从基于等位基因共享的连锁分析的检验统计量出发，我们提出了一个相关的单参数模型。在一般的缺失数据模式下，该模型允许精确计算似然比和LOD分数，并已通过对现有软件的简单修改来实现。最重要的是，可以进行准确的连锁测试。使用一个例子，我们表明，一些以前建议的方法来处理不完全的信息数据可以是不可接受的保守。这种模式可能无法很好地执行的情况进行了讨论，并提出了一种替代模型，需要额外的计算。
Starting with a test statistic for linkage analysis based on allele sharing, we propose an associated one-parameter model. Under general missing-data patterns, this model allows exact calculation of likelihood ratios and LOD scores and has been implemented by a simple modification of existing software. Most important, accurate linkage tests can be performed. Using an example, we show that some previously suggested approaches to handling less than perfectly informative data can be unacceptably conservative. Situations in which this model may not perform well are discussed, and an alternative model that requires additional computations is suggested.