Antibodies to β2-glycoprotein I and clinical manifestations in patients with systemic lupus erythematosus
Antibodies to β2-glycoprotein I and clinical manifestations in patients with systemic lupus erythematosus
复制标题
系统性红斑狼疮患者β2-糖蛋白I抗体及临床表现
DOI：
--
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
T. Koike
中科院分区：
文献类型：
--
作者：
A. Tsutsumi;E. Matsuura;K. Ichikawa;A. Fujisaku;M. Mukai;Seiichi Kobayashi;T. Koike
目的探讨系统性红斑狼疮（SLE）患者抗心磷脂抗体（aCL）是否与β 2-糖蛋白I （β 2GPI）结合，并探讨SLE患者IgG和/或IgM抗β 2GPI抗体的存在与临床表现的关系。方法采用不依赖磷脂的酶免疫分析法检测308例日本SLE患者的IgG和IgM抗- 2GPI。检查了与临床病史和各种实验室数据的关系。结果常规酶免疫法测定抗- β - 2GPI与aCL值具有较强的相关性，但抗- β - 2GPI法对区分β - 2GPI依赖型aCL和β - 2GPI非依赖型aCL更有效。IgG抗- 2GPI的存在与血栓形成史的频率增加有关。各种实验室数据的比较表明，抗- 2GPI的滴度可能随疾病活动而波动。结论：致病性aCL是针对结构改变的β 2GPI的，酶免疫测定抗β 2GPI可能有助于评估SLE患者血栓形成风险和监测临床病程。
OBJECTIVE To investigate whether anticardiolipin antibodies (aCL) in patients with systemic lupus erythematosus (SLE) bind to beta 2-glycoprotein I (beta 2GPI), and to search for a relationship between the presence of IgG and/or IgM anti-beta 2GPI antibody and clinical manifestations in SLE patients. METHODS IgG and IgM anti-beta 2GPI in 308 Japanese SLE patients were measured using phospholipid-independent enzyme immunoassays. Relationships to clinical histories and to various laboratory data were examined. RESULTS The values of anti-beta 2GPI and aCL, as measured by conventional enzyme immunoassay, showed a strong correlation, but the anti-beta 2GPI assay was more useful in distinguishing beta 2GPI-dependent aCL from beta 2GPI-independent aCL. The presence of IgG anti-beta 2GPI was associated with an increased frequency of a history of thrombosis. Comparisons of various laboratory data suggested that the titer of anti-beta 2GPI may fluctuate with disease activity. CONCLUSION The results suggest that pathogenic aCL is directed against structurally altered beta 2GPI and that enzyme immunoassay for anti-beta 2GPI may prove useful in evaluating the risk of thrombosis and monitoring the clinical course in patients with SLE.
登录
查看更多内容
系统性红斑狼疮患者抗心磷脂抗体单次检测的临床意义。
DOI：
10.1016/s0002-9343(88)80229-8
发表时间：
1988
期刊：
The American journal of medicine
影响因子：
--
作者：
Kalunian,KC;Peter,JB;Middlekauff,HR;Sayre,J;Ando,DG;Mangotich,M;Hahn,BH
通讯作者：
Hahn,BH
心磷脂抗体可作为系统性红斑狼疮妊娠患者胎儿窘迫或死亡的预测因子。
DOI：
10.1056/nejm198507183130304
发表时间：
1985
期刊：
The New England journal of medicine
影响因子：
--
作者：
Lockshin,MD;Druzin,ML;Goei,S;Qamar,T;Magid,MS;Jovanovic,L;Ferenc,M
通讯作者：
Ferenc,M
抗心磷脂抗体与儿童系统性红斑狼疮疾病表现的关系。
DOI：
--
发表时间：
1988
期刊：
The Journal of rheumatology
影响因子：
--
作者：
Shergy,WJ;Kredich,DW;Pisetsky,DS
通讯作者：
Pisetsky,DS
“抗心磷脂”自身抗体在缺乏磷脂的情况下识别 β2-糖蛋白 I。
DOI：
--
发表时间：
1995
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Roubey,RA;Eisenberg,RA;Harper,MF;Winfield,JB
通讯作者：
Winfield,JB