A novel computational tool for tracking cancer energy hijacking from immune cells.
A novel computational tool for tracking cancer energy hijacking from immune cells.
复制标题
DOI：
10.1002/ctm2.1533
复制
发表时间：
2024-01
影响因子：
10.6
通讯作者：
中科院分区：
文献类型：
--
作者：
最近的研究揭示了恶性癌细胞劫持附近T细胞线粒体的新的生物学过程，为免疫逃避提供了另一种潜在的机制。我们通过MERCI进一步在单细胞基因组水平上证实了这一过程，MERCI是一种跟踪线粒体（MT）转移的新算法。将MERCI应用于人类癌症样本，发现了一种与MT劫持相关的新癌症表型，与肿瘤快速增殖和患者生存率低相关。这一发现揭示了当前癌症免疫疗法的局限性，并提出了针对MT转移的新治疗途径，以提高癌症治疗效果。
Recent studies revealed a new biological process that malignant cancer cells hijack mitochondria from nearby T cells, providing another potential mechanism for immune evasion. We further confirmed this process at the single‐cell genomic level through MERCI, a novel algorithm for tracking mitochondrial (MT) transfer. Applied to human cancer samples, MERCI identified a new cancer phenotype linked to MT hijacking, correlating with rapid tumour proliferation and poor patient survival. This discovery offers insights into the limitations of current cancer immunotherapies and suggests new therapeutic avenues targeting MT transfer to enhance cancer treatment efficacy.