Artificial Micro/Nanomachines for Bioapplications: Biochemical Delivery and Diagnostic Sensing
Artificial Micro/Nanomachines for Bioapplications: Biochemical Delivery and Diagnostic Sensing
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DOI：
10.1002/adfm.201705867
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发表时间：
2018-06-20
影响因子：
19
通讯作者：
Fan, Donglei
中科院分区：
文献类型：
--
作者：
Kim, Kwanoh;Guo, Jianhe;Fan, Donglei
人工纳米机器的最新进展为生化输送和诊断方面的重大挑战提供了有前途的解决方案。在这项工作中，微/纳米机器的合成微/纳米结构的应用程序中的交付和检测的生物分子的进展进行了审查，沿着与每种类型的机器的优点和缺点的讨论。根据微/纳机器人的工作机理，包括通过磁场、电场和声场以及化学反应实现的运动驱动，对微/纳机器人进行了分类。微/纳米机器的发展进行了深入的讨论，在制造，推进和运动控制，加载和释放的微/纳米物质，和生化传感。人造微型机器的快速发展为未来智能纳米机器人和纳米工厂铺平了道路，这些机器人和纳米工厂可以彻底改变社会。
Recent progress in artificial nanomachines offers promising solutions to grand challenges in biochemical delivery and diagnostics. In this work, advances of micro/nanomachines made of synthesized micro/nanostructures for applications in delivery and detection of biomolecules are reviewed, along with a discussion of pros and cons of each type of machine. The review of micro/nanomachines is categorized according to their working mechanisms, including motion actuation realized by magnetic, electric, and acoustic fields and chemical reactions. The developments of micro/nanomachines are discussed in depth in the fabrication, propulsion, and motion control, loading and releasing of micro/nanosubstances, and biochemical sensing. The rapid development of man-made miniaturized machines paves the road toward future intelligent nanorobots and nanofactories that can revolutionize society.