Terminal nerve and vision
Terminal nerve and vision
复制标题
DOI：
10.1002/jemt.20108
复制
发表时间：
2004-09-01
影响因子：
2.5
通讯作者：
Wagner, HJ
中科院分区：
文献类型：
--
作者：
Behrens, U;Wagner, HJ
脊椎动物视网膜接受来自中枢神经系统不同部分的传出输入。传出纤维被认为影响视网膜信息处理，但其功能作用还不清楚。在硬骨鱼视网膜中，最好描述的视网膜纤维系统之一属于终末神经复合体。来自终末神经节的含有促性腺激素释放激素（GnRH）和软体动物心脏兴奋性四肽（FMRFamide）的纤维在视网膜中的内核和内丛状层的边界处形成致密的纤维丛。硬骨鱼类视网膜多巴胺能网间形细胞胞体周围的含肽纤维。体外实验表明，外源性GnRH介导多巴胺能对膜电位和锥体水平细胞树突尖端（小刺）形态的影响。这些作用可以被GnRH拮抗剂特异性阻断，表明多巴胺的释放和多巴胺依赖性对视网膜神经元光适应的作用受到终末神经复合体的影响。最近的数据表明，嗅觉信息对视网膜生理有影响，但其确切作用尚不清楚。终末神经复合体的传出纤维是最早的视网膜纤维系统之一，其纤维的来源、它们的细胞靶点以及几种生理、形态和行为效应是已知的。因此，终末神经复合体是一个模型系统，用于分析受不同纤维投射影响的局部信息处理。(C)2004年威利-利斯。Inc.
The vertebrate retina receives efferent input from different parts of the central nervous system. Efferent fibers are thought to influence retinal information processing but their functional role is not well understood. One of the best-described retinopetal fiber systems in teleost retinae belongs to the terminal nerve complex. Gonadotropin-releasing hormone (GnRH) and molluscan cardioexcitatory tetrapeptide (FMRFamide)-containing fibers from the ganglion of the terminal nerve form a dense fiber plexus in the retina at the border of the inner nuclear and inner plexiform layer. Peptide-containing fibers surround and contact perikarya of dopaminergic interplexiform cells in teleost retina. In vitro experiments demonstrated that exogenously supplied GnRH mediates dopaminergic effects on the membrane potential and on the morphology of dendritic tips (spinules) of cone horizontal cells. These effects can be specifically blocked by GnRH-antagonists, indicating that the release of dopamine and dopamine-dependent effects on light adaptation of retinal neurons are affected by the terminal nerve complex. Recent data have shown that olfactory information has an impact on retinal physiology, but its precise role is not clear. The efferent fiber of the terminal nerve complex is one of the first retinopetal fiber systems for which the sources of the fibers, their cellular targets, and several physiological, morphological, and behavioral effects are known. The terminal nerve complex is therefore a model system for the analysis of local information processing which is influenced by a distinct fiber projection. (C) 2004 Wiley-Liss. Inc.