Arf GTPase interplay with Rho GTPases in regulation of the actin cytoskeleton.
Arf GTPase interplay with Rho GTPases in regulation of the actin cytoskeleton.
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DOI：
10.1080/21541248.2017.1329691
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发表时间：
2019-11
期刊：
影响因子：
--
通讯作者：
Koronakis V
中科院分区：
文献类型：
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作者：
Singh V;Davidson AC;Hume PJ;Humphreys D;Koronakis V
小gtpase的Arf和Rho亚家族是核苷酸依赖的分子开关，作为囊泡运输和肌动蛋白细胞骨架组织的主要调节剂。小的gtpase通过不同的称为效应体的结合伙伴库来高保真地控制细胞过程。虽然我们对这些gtp酶如何单独起作用有了很大的了解，但对它们如何合作，特别是在控制效应器方面，我们知之甚少。这篇综述强调了Arf GTPases如何与Rac1合作，通过募集和激活波调节复合体（WRC）来调节膜上的肌动蛋白细胞骨架动力学，WRC是一种支撑板足形成和巨噬细胞增多症的Rho效应物。这提供了对肌动蛋白细胞骨架的Arf调控的深入了解，同时将焦点放在小GTPase的合作上，其在基础细胞生物学和与致病菌相互作用中的重要性的新证据。
The Arf and Rho subfamilies of small GTPases are nucleotide-dependent molecular switches that act as master regulators of vesicular trafficking and the actin cytoskeleton organization. Small GTPases control cell processes with high fidelity by acting through distinct repertoires of binding partners called effectors. While we understand a great deal about how these GTPases act individually, relatively little is known about how they cooperate, especially in the control of effectors. This review highlights how Arf GTPases collaborate with Rac1 to regulate actin cytoskeleton dynamics at the membrane via recruiting and activating the Wave Regulatory Complex (WRC), a Rho effector that underpins lamellipodia formation and macropinocytosis. This provides insight into Arf regulation of the actin cytoskeleton, while putting the spotlight on small GTPase cooperation with emerging evidence of its importance in fundamental cell biology and interactions with pathogenic bacteria.