Serum Human Epididymis Protein 4 as a Novel Biomarker in Identifying Patients With Interstitial Lung Disease in Rheumatoid Arthritis.
Serum Human Epididymis Protein 4 as a Novel Biomarker in Identifying Patients With Interstitial Lung Disease in Rheumatoid Arthritis.
复制标题
DOI：
10.3389/fmed.2021.755268
复制
发表时间：
2021
影响因子：
3.9
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Liang L;Chen J;Di C;Zhan M;Bao H;Xia C;Fan C;Liu Y
目的：人附睾蛋白4 （HE4）与肺受累有关。我们旨在探讨HE4在类风湿关节炎（RA）患者临床分层中的临床应用。方法：本研究包括一个由70名RA患者和64名健康对照（hc）组成的发现队列，以及一个由98名RA患者和75名hc组成的验证队列。用电化学发光分析仪测定人附睾蛋白4。结果：与hcc患者相比，RA患者的HE4水平显著升高。RA和hc患者的HE4阳性率在发现组分别为50.0%和0%，在验证组分别为53.1和1.3%。当根据HE4状态对RA患者进行亚组时，HE4阳性组比HE4阴性组显示出更高的间质性肺疾病（ILD）患病率（发现组28.6%比11.4%，验证组57.7%比8.7%）。HE4水平与肺损伤程度呈正相关。受试者工作曲线（ROC）分析显示，区分RA-ILD与RA-non -ILD的最佳截断值为104.3 pmol/L，曲线下面积（AUC）为0.790。多因素logistic回归分析表明，高水平HE4独立识别RA-ILD患者（OR, 9.080, p < 0.001）。结论：我们的研究结果显示了HE4在RA风险分层中的新作用，表明将HE4引入目前的RA测试组可能作为识别RA患者进行进一步RA- ild检查的指标，如高分辨率计算机断层扫描（HRCT）。
Objective: Human epididymis protein 4 (HE4) have been implicated in the pulmonary involvements. We aimed to investigate the clinical utility of HE4 in clinical stratification in patients with rheumatoid arthritis (RA). Methods: This study included a discovery cohort comprising 70 RA patients and 64 healthy controls (HCs), and a validation cohort comprising 98 RA patients and 75 HCs. Human epididymis protein 4 were determined by electrochemical luminescence analyzer. Results: The levels of HE4 were significantly elevated in patients with RA compared to HCs. The positive rates of HE4 in patients with RA and HCs were 50.0% and 0, respectively, in the discovery cohort and 53.1 and 1.3%, respectively, in the validation cohort. When RA patients were subgrouped according to HE4 status, HE4-positive group displayed higher prevalence of interstitial lung disease (ILD) compared to HE4-negative group (28.6 vs. 11.4% in discovery cohort and 57.7 vs. 8.7% in the validation cohort). A positive correlation between the levels of HE4 with the degree of lung impairment was identified. Receiver operating curve (ROC) analysis revealed an optimal cut-off value of 104.3 pmol/L in HE4 for distinguishing RA-ILD from RA-non ILD with the areas under the curve (AUC) of 0.790. Multivariate logistic regression analysis illustrated that high levels of HE4 independently identified patients with RA-ILD (OR, 9.080, p < 0.001). Conclusion: Our findings showed a novel role of HE4 in RA risk stratification, suggest that introducing HE4 to the current RA test panel may serve as an indicator in identifying RA patients for further RA-ILD workups, such as high-resolution computed tomography (HRCT).
登录
查看更多内容
影响因子：
4.7
作者：
Sparks JA;Chang SC;Liao KP;Lu B;Fine AR;Solomon DH;Costenbader KH;Karlson EW
通讯作者：
Karlson EW
影响因子：
5.2
作者：
Nagy, Bela, Jr.;Bene, Zsolt;Balogh, Istvan
通讯作者：
Balogh, Istvan
影响因子：
5.8
作者：
Bingle L;Cross SS;High AS;Wallace WA;Rassl D;Yuan G;Hellstrom I;Campos MA;Bingle CD
通讯作者：
Bingle CD
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
5.5
作者：
Wang, Yukai;Chen, Shaoqi;Furst, Daniel E.
通讯作者：
Furst, Daniel E.