Functional symmetry of endomembranes
Functional symmetry of endomembranes
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DOI：
10.1091/mbc.e06-10-0933
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发表时间：
2007-04-01
影响因子：
3.3
通讯作者：
Goud, Bruno
中科院分区：
文献类型：
--
作者：
Saraste, Jaakko;Goud, Bruno
在高等真核细胞中，由空泡、小管和囊泡组成的多形隔室从内质网（ER）和质膜移动到细胞中心，分别在早期生物合成运输和内吞作用中起作用。除了运输货物到高尔基体和溶酶体，这些隔间的主要任务是促进广泛的膜再循环。内吞膜系统传统上分为早期（分选）内体、晚期内体和内吞再循环室（ERC）。最近对ER和高尔基体之间的中间隔室（10）的研究表明，它也由外围（“早期”）和集中（“晚期”）结构以及第三组分组成，在此称为生物合成再循环隔室（BRC）。我们认为ERC和BRC作为长寿的“镜像隔间”存在于细胞中心，它们也具有在细胞活化过程中扩展和动员的能力。这些考虑强调内膜隔室的功能对称性，这为细胞分裂、极化和分化过程中发生的膜重排提供了基础。
In higher eukaryotic cells pleiomorphic compartments composed of vacuoles, tubules and vesicles move from the endoplasmic reticulum (ER) and the plasma membrane to the cell center, operating in early biosynthetic trafficking and endocytosis, respectively. Besides transporting cargo to the Golgi apparatus and lysosomes, a major task of these compartments is to promote extensive membrane recycling. The endocytic membrane system is traditionally divided into early (sorting) endosomes, late endosomes and the endocytic recycling compartment (ERC). Recent studies on the intermediate compartment (10 between the ER and the Golgi apparatus suggest that it also consists of peripheral ("early") and centralized ("late") structures, as well as a third component, designated here as the biosynthetic recycling compartment (BRC). We propose that the ERC and the BRC exist as long-lived "mirror compartments" at the cell center that also share the ability to expand and become mobilized during cell activation. These considerations emphasize the functional symmetry of endomembrane compartments, which provides a basis for the membrane rearrangements taking place during cell division, polarization, and differentiation.