The developmental expression of choline acetyltransferase (ChAT) and the neuropeptide VIP in chick sympathetic neurons: evidence for different regulatory events in cholinergic differentiation
The developmental expression of choline acetyltransferase (ChAT) and the neuropeptide VIP in chick sympathetic neurons: evidence for different regulatory events in cholinergic differentiation
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DOI：
10.1016/s0925-4773(97)00135-4
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发表时间：
1997-11-01
影响因子：
2.6
通讯作者：
Rohrer, H
中科院分区：
文献类型：
--
作者：
Ernsberger, U;Patzke, H;Rohrer, H
鸡交感神经元的胆碱能特性在椎旁神经节发育的早期就可检测到，并在靶点接触后成熟。胆碱能标记胆碱乙酰转移酶（ChAT）是第一次检测到在胚胎第6天，其表达部分重叠的去甲肾上腺素能标记酪氨酸羟化酶（TH）。在胚胎晚期，当交感神经元已经建立靶接触时，神经节由两个主要的神经元群体组成，TH阳性去甲肾上腺素能神经元和胆碱能神经元，其在该阶段除了ChAT之外还表达血管活性肠肽（VIP）。交感神经元对神经因子睫状神经营养因子（CNTF）反应的变化是交感神经元成熟的标志。这些研究结果表明，神经递质特性的表达控制差异之前和期间的目标神经支配。(C)1997 Elsevier Science爱尔兰有限公司
Cholinergic properties in chick sympathetic neurons are detectable early during development of paravertebral ganglia and mature after target contact. The cholinergic marker choline acetlytransferase (ChAT) is first detectable at embryonic day 6 and its expression partly overlaps with that of the noradrenergic marker tyrosine hydroxylase (TH). At late embryonic stages, when sympathetic neurons have established target contact, ganglia consist of two major neuronal populations, TH-positive noradrenergic neurons and cholinergic neurons that at this stage express vasoactive intestinal peptide (VIP) in addition to ChAT. The maturation of sympathetic neurons is paralleled by changes in their response to the neurokine ciliary neurotrophic factor (CNTF). These findings suggest that expression of neurotransmitter properties is controlled differentially before and during target innervation. (C) 1997 Elsevier Science Ireland Ltd.