Tandem Catalysis: Rh(III)-Catalyzed C–H Allylation/Pd(II)-Catalyzed N-Allylation Toward the Synthesis of Vinyl-Substituted N-Heterocycles
Tandem Catalysis: Rh(III)-Catalyzed C–H Allylation/Pd(II)-Catalyzed N-Allylation Toward the Synthesis of Vinyl-Substituted N-Heterocycles
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DOI：
10.1021/cs501601c
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发表时间：
2015-01
期刊：
影响因子：
12.9
通讯作者：
Shang‐Shi Zhang;Jia-Qiang Wu;Xu-Ge Liu;Honggen Wang
中科院分区：
文献类型：
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作者：
Shang‐Shi Zhang;Jia-Qiang Wu;Xu-Ge Liu;Honggen Wang
实现了Rh(III)/Pd(II)的串联催化，使两个重要的N-杂环能够快速地获得具有合成价值的乙烯基取代基。反应在温和的反应条件下进行，操作简单。观察到良好的底物范围和较高的区域和立体选择性。乙烯基团被证明是进行官能团相互转化的可靠手柄。烯烃效应是该工艺成功的关键因素。
Tandem catalysis by Rh(III)/Pd(II) was realized, enabling rapid access to two important N-heterocycles that bear a synthetically valuable vinyl substituent. The reaction occurred under mild reaction conditions and was easy to handle. Good substrate scope and high regio- and stereoselectivities were observed. The vinyl group was demonstrated to be a reliable handle for functional group interconversions. The alkene effect was found to be the key factor for the success of this process.