Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: epidemiology, pathogenesis and clinical characteristics
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: epidemiology, pathogenesis and clinical characteristics
复制标题
DOI：
10.26355/eurrev_201808_15635
复制
发表时间：
2018-08-01
影响因子：
3.3
通讯作者：
Zaher, W. A.
中科院分区：
文献类型：
--
作者：
Nassar, M. S.;Bakhrebah, M. A.;Zaher, W. A.
目的：中东呼吸综合征冠状病毒(MERS-CoV)感染是一种世界性的健康危机。该病的早期诊断和管理仍然是一项重大挑战。本研究旨在探讨MERS冠状病毒感染的流行病学、发病机制和临床表现。材料与方法：应用计算机检索英文文献，检索词为“PubMed”、“Medline”、“Web of Knowledge”、“EMbase”和“Google Scholar”，检索词为“MERS”、“MERS”、“MERS-CoV”、“Epidemology”、“传播学”、“病因学”、“临床特征”，限定文章语言种类为英文。我们回顾了有关MERS冠状病毒感染的流行病学、发病机制和临床表现的文献，并记录了所需的信息。结果：2012年6月至2018年4月，全球MERS冠状病毒感染的流行率为2206人。沙特阿拉伯报告的病例数为1831例(83%)，死亡率为787例(35.67%)。主要临床表现为发热、寒战、全身肌痛、咳嗽、气短、恶心、呕吐和腹泻。与年龄相关的MERS冠状病毒感染率在患有慢性衰弱疾病的老年人中最高，如肺部疾病、终末期肾脏疾病、糖尿病和恶性肿瘤。结论：MERS冠状病毒感染是一种新兴的全球卫生问题，影响着各大洲27个国家的人民。MERS冠状病毒感染主要在中东、欧洲、非洲、亚洲和北美被发现。及早发现和处理MERS冠状病毒感染对于最大限度地减少疾病负担至关重要。
OBJECTIVE: Middle East Respiratory Syndrome Coronavirus-(MERS-CoV) infection is an evolving worldwide health crisis. The early diagnosis and management of the disease remains a major challenge. This study designed to discuss the epidemiology, pathogenesis and clinical appearances of MERS-CoV infections.MATERIALS AND METHODS: We conducted a broad search of the English-language literature in "PubMed" "Medline" "Web of knowledge", "EMBASE" and "Google Scholar" World Health Organization-WHO" using the key words "Middle East Respiratory Syndrome", "MERS", "MERS-CoV" "Epidemiology" "Transmission" "Pathogenesis" "Clinical Characteristics". We reviewed the literature on epidemiology, pathogenesis and clinical appearances of MERS-CoV infection and the required information was documented.RESULTS: The global prevalence of MERS-CoV infection from June 2012 to April 2018 is 2206 people. The number of cases reported from Saudi Arabia is 1831 (83%) with mortality rate of 787 (35.67%). The main clinical manifestations are fever, chills, generalized myalgia, cough, shortness of breath, nausea, vomiting and diarrhea. The age-allied prevalence of MERS-CoV was highest amongst elderly people with chronic debilitating diseases such as pulmonary diseases, end-stage renal illness, diabetes mellitus and malignancy.CONCLUSIONS: MERS-CoV infection is an emerging global health concern, affected people in 27 countries in the various continents. MERS-CoV infection has been identified mainly in the Middle East, Europe, Africa, Asia and North America. Early detection and management of MERS-CoV infection is of critical importance to minimize the burden of the disease.