Lipotropes, immunocompetence, and cancer.
Lipotropes, immunocompetence, and cancer.
复制标题
抗脂剂、免疫功能和癌症。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
De Camargo Jl
中科院分区：
文献类型：
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作者：
Newbene Pm;Nauss Km;De Camargo Jl
脂肪酸（胆碱，蛋氨酸，叶酸和维生素B12）是细胞和亚细胞水平正常代谢功能所必需的。它们中的任何一种或全部的缺陷对甲基代谢的影响对细胞大分子的合成和细胞增殖具有深远的影响。在实验动物中，亲脂蛋白缺乏导致免疫能力降低和对多种类型癌症的易感性增加。目前面临的一个挑战是确定亲脂蛋白、免疫系统和癌症之间的联系，并确定可用于癌症预防的机制。
: Lipotropes (choline, methionine, folic acid, and vitamin B12) are required for normal metabolic function at the cellular and subcellular levels. Deficiencies of any or all of them to a point of influence on methyl group metabolism has a profound effect on synthesis of cellular macromolecules and on cell proliferation. Lipotrope deficiency results in a diminished immunocompetence and an increased susceptibility to a number of types of cancer in experimental animals. A challenge now being addressed is to identify the linkage between lipotropes, the immune system, and cancer and to determine mechanisms which can be useful in cancer prevention.