Maculopapular eruptions associated toCOVID-19: A subanalysis of theCOVID-Pielstudy
Maculopapular eruptions associated toCOVID-19: A subanalysis of theCOVID-Pielstudy
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DOI：
10.1111/dth.14170
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发表时间：
2020-09-09
影响因子：
3.6
通讯作者：
Garcia-Doval, Ignacio
中科院分区：
文献类型：
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作者：
Catala, Alba;Galvan-Casas, Cristina;Garcia-Doval, Ignacio
先前的一项研究已经定义了COVID-19表现的斑丘疹亚型。我们研究的目的是描述和分类与COVI-19相关的斑丘疹。我们进行了亚组分析的斑丘疹病例发现在以前的横断面研究。使用共识，我们定义了七种临床模式。我们描述了患者的人口统计学资料，患者接受的治疗和每种模式的特点。共识导致描述了7种主要斑丘疹模式：麻疹样（45.5%）、其他斑丘疹（20.0%）、紫癜性（14.2%）、多形性红斑样（9.7%）、玫瑰色糠疹样（5.7%）、持续性隆起红斑样（2.3%）和滤泡周围（2.3%）。在大多数情况下，斑丘疹与其他COVID-19表现的发作同时（61.9%）或随后（34.1%）。最常见的是咳嗽（76%）、呼吸困难（72%）、发热（88%）和乏力（62%）。因肺炎住院的情况很常见（61%）。药物摄入频繁（78%）。与斑丘疹相关的实验室改变为高C反应蛋白、高D二聚体、淋巴细胞减少、高铁蛋白、高LDH和高IL-6。我们研究的主要局限是无法确定每种模式的因果关系。总之，我们提供了与COVID-19相关的皮肤斑丘疹表现的描述。COVID-19的皮肤表现范围广泛，可以模仿其他皮肤病。
A previous study has defined the maculopapular subtype of manifestations of COVID-19. The objective of our study was to describe and classify maculopapular eruptions associated with COVI-19. We carried out a subanalysis of the maculopapular cases found in the previous cross-sectional study. Using a consensus, we defined seven clinical patterns. We described patient demographics, the therapy received by the patient and the characteristics of each pattern. Consensus lead to the description of seven major maculopapular patterns: morbilliform (45.5%), other maculopapular (20.0%), purpuric (14.2%), erythema multiforme-like (9.7%), pytiriasis rosea-like (5.7%), erythema elevatum diutinum-like (2.3%), and perifollicular (2.3%). In most cases, maculopapular eruptions were coincident (61.9%) or subsequent (34.1%) to the onset of other COVID-19 manifestations. The most frequent were cough (76%), dyspnea (72%), fever (88%), and astenia (62%). Hospital admission due to pneumonia was frequent (61%). Drug intake was frequent (78%). Laboratory alterations associated with maculo-papular eruptions were high C-reactive protein, high D-Dimer, lymphopenia, high ferritin, high LDH, and high IL-6. The main limitation of our study was the impossibility to define the cause-effect relationship of each pattern. In conclusion, we provide a description of the cutaneous maculopapular manifestations associated with COVID-19. The cutaneous manifestations of COVID-19 are wide-ranging and can mimic other dermatoses.