Functionalized Mesoporous Silica via an Aminosilane Surfactant Ion Exchange Reaction: Controlled Scaffold Design and Nitric Oxide Release.
Functionalized Mesoporous Silica via an Aminosilane Surfactant Ion Exchange Reaction: Controlled Scaffold Design and Nitric Oxide Release.
复制标题
通过氨基硅烷表面活性剂离子交换反应功能化介孔二氧化硅：受控支架设计和一氧化氮释放。
DOI：
10.1021/acsami.5b10942
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发表时间：
2016
影响因子：
9.5
通讯作者：
Schoenfisch,MarkH
中科院分区：
文献类型：
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作者：
Soto,RobertJ;Yang,Lei;Schoenfisch,MarkH
采用氨基硅烷-模板表面活性剂离子交换反应制备了释放一氧化氮的介孔二氧化硅纳米颗粒(MSN)。首先，在十六烷基三甲基溴化铵(CTAB)存在下，在碱性条件下合成了裸二氧化硅颗粒。通过将氨基硅烷直接加入到粒子溶胶中，并在阳离子氨基硅烷与CTAB之间进行相应的离子交换反应，将这些粒子与一氧化氮(NO)给体前体(即仲胺)功能化，在仲胺上形成NO供体，生成NO释放的MSN。基于离子交换的MSN修饰方法的调整允许制备范围从30到1100 nm的单分散粒子。无论大小，MSN储存了相当数量的NO(0.4~1.5mmolmg-1)，NO释放持续时间(1~33h)取决于氨基硅烷的修饰。实现了对NO释放性能和颗粒大小的独立控制，显示了这种新型MSN合成相对于传统的共缩合和表面接枝策略的灵活性。
Nitric oxide-releasing mesoporous silica nanoparticles (MSNs) were prepared using an aminosilane-template surfactant ion exchange reaction. Initially, bare silica particles were synthesized under basic conditions in the presence of cetyltrimethylammonium bromide (CTAB). These particles were functionalized with nitric oxide (NO) donor precursors (i.e., secondary amines) via the addition of aminosilane directly to the particle sol and a commensurate ion exchange reaction between the cationic aminosilanes and CTAB.N-Diazeniumdiolate NO donors were formed at the secondary amines to yield NO-releasing MSNs. Tuning of the ion exchange-based MSN modification approach allowed for the preparation of monodisperse particles ranging from 30 to 1100 nm. Regardless of size, the MSNs stored appreciable levels of NO (0.4–1.5 μmol mg–1) with tunable NO release durations (1–33 h) dependent on the aminosilane modification. Independent control of NO release properties and particle size was achieved, demonstrating the flexibility of this novel MSN synthesis over conventional co-condensation and surface grafting strategies.