Effects of GV20 Acupuncture on Cerebral Blood Flow Velocity of Middle Cerebral Artery and Anterior Cerebral Artery Territories, and CO2 Reactivity During Hypocapnia in Normal Subjects
Effects of GV20 Acupuncture on Cerebral Blood Flow Velocity of Middle Cerebral Artery and Anterior Cerebral Artery Territories, and CO2 Reactivity During Hypocapnia in Normal Subjects
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DOI：
10.1089/acm.2010.0232
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发表时间：
2011-03-01
影响因子：
2.6
通讯作者：
Bae, Hyung-sup
中科院分区：
文献类型：
--
作者：
Byeon, Hyung-sik;Moon, Sang-kwan;Bae, Hyung-sup
目的：针灸作为一种替代和补充治疗方法在现代医学从业者中越来越受欢迎。然而，其治疗作用的机制仍不确定。本研究选择GV20穴位作为穴位效应的评价指标，假设其刺激引起脑血管反应。设计和地点：对10名健康男性受试者(平均年龄25.6±0.8岁)进行GV20针刺治疗对大脑中动脉(MCA)和大脑前动脉(ACA)血流速度及低碳酸血症时二氧化碳反应性的影响。分别在安静时和低碳酸血症时进行测量，并在不同的大脑动脉区域重复测量，每次重复4次，间隔1周。用经颅多普勒血流仪检测大脑中动脉和大脑中动脉血流速度。血流速度校正为呼气末二氧化碳分压(P-ETCO2)的40毫米汞柱，并表示为CV40。CO2反应性以平均血流速度/mm HgPETCO2的变化百分比来衡量。结果：GV20针刺治疗后，安静时平均MCA和ACA血流速度、CV40和低碳酸血症时的CO2反应性显著增加，而安静时平均动脉压和脉率无明显变化。MCA和ACA血流速度的增加与GV20针刺治疗后CO2反应性的改善有关。结论：GV20针刺治疗增加了脑血流量。这项小规模研究的结果为针灸疗效提供了初步证据。
Objectives: Acupuncture has been gaining popularity among practitioners of modern medicine as an alternative and complementary treatment. However, the mechanism of its therapeutic effect still remains uncertain. The present study chose the GV20 acupoint to evaluate acupoint effectiveness, hypothesizing that its stimulation induces cerebrovascular responses.Design and setting: The effects of GV20 acupuncture treatment on middle cerebral artery (MCA) and anterior cerebral artery (ACA) blood flow velocities, and CO2 reactivity during hypocapnia were evaluated in 10 healthy male subjects (mean age 25.6 +/- 0.8 years). Measurements were done at rest and during hypocapnia, and were repeated four times each at different cerebral artery territories with an interval of 1 week. MCA and ACA blood flow velocities were measured with a transcranial Doppler flowmeter. Blood flow velocity was corrected to 40 mm Hg of end-tidal CO2 partial pressure (P-ETCO2), and was expressed as CV40. CO2 reactivity was measured as percent change in mean blood flow velocity/mm Hg PETCO2.Results: Mean MCA and ACA blood flow velocities at rest, CV40, and CO2 reactivity during hypocapnia increased significantly after GV20 acupuncture treatment, whereas mean arterial blood pressure and pulse rate at rest did not change significantly. The increases in MCA and ACA blood flow velocity were associated with improved CO2 reactivity after GV20 acupuncture treatment.Conclusions: The data suggest that GV20 acupuncture treatment increases cerebral blood flow. The results of this small-scale study provide preliminary evidence for acupuncture effectiveness.