GENERIC MODELING OF COOPERATIVE GROWTH-PATTERNS IN BACTERIAL COLONIES
GENERIC MODELING OF COOPERATIVE GROWTH-PATTERNS IN BACTERIAL COLONIES
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DOI：
10.1038/368046a0
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发表时间：
1994-03-03
期刊：
影响因子：
64.8
通讯作者：
VICSEK, T
中科院分区：
文献类型：
--
作者：
BENJACOB, E;SCHOCHET, O;VICSEK, T
生物群落必须经常科普不利的环境条件（1，2）。为此，他们发展了复杂的合作行为模式（3-10）。已经发现，这种行为可以导致细菌菌落表现出与在非生命系统中的非平衡生长过程期间观察到的那些相似的复杂生长模式（11），后者的一些定性特征可以用来解释细菌生长的复杂模式（12-18）。在这里，我们表明，一个简单的细菌生长模型可以重现所观察到的生长模式的显着特征。该模型采用了随机步行者，代表细菌的聚集体，响应于营养浓度梯度而移动，并通过趋化性“反馈”相互通信。这些简单的特征允许殖民地有效地响应不利的生长条件，并在宽范围的长度尺度上产生自组织。
BACTERIAL colonies must often cope with unfavourable environmental conditions(1,2). To do so, they have developed sophisticated modes of cooperative behaviour(3-10). It has been found that such behaviour can cause bacterial colonies to exhibit complex growth patterns similar to those observed during non-equilibrium growth processes in non-living systems(11) some of the qualitative features of the latter may be invoked to account for the complex patterns of bacterial growth(12-18). Here we show that a simple model of bacterial growth can reproduce the salient features of the observed growth patterns. The model incorporates random walkers, representing aggregates of bacteria, which move in response to gradients in nutrient concentration and communicate with each other by means of chemotactic 'feedback'. These simple features allow the colony to respond efficiently to adverse growth conditions, and generate self-organization over a wide range of length scales.