Mapping the lung
Mapping the lung
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DOI：
10.1126/science.aaw6775
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发表时间：
2019
期刊：
影响因子：
56.9
通讯作者：
Mildner
中科院分区：
文献类型：
--
作者：
Mildner
在过去的十年中，巨噬细胞生物学在了解其发育和功能方面经历了一场革命。巨噬细胞是驻留在所有哺乳动物组织中的常驻免疫哨兵，在那里它们摄取和消化外来物质和细胞残留物，并帮助协调免疫反应。常驻巨噬细胞共享许多通用功能，但在解剖结构不同的巨噬细胞群体之间存在转录和功能多样性，这表明组织微环境是影响巨噬细胞功能的重要因素（1,2）。在本期杂志的第1190页，Chakarovet等人(3)在肺中发现了两种间质巨噬细胞。这些巨噬细胞亚群不仅在表型上不同，而且在组织内定位上也有明显差异：一群巨噬细胞靠近组织神经束，而另一群巨噬细胞与血管密切相关，在病理过程中维持血管完整性和抗纤维化活性方面发挥重要作用。这为巨噬细胞种群的多样性和功能二分法提供了新的见解，甚至在单个组织内。
Over the past decade, macrophage biology has undergone a revolution with regard to understanding their development and function. Macrophages are resident immune sentinels that reside in all mammalian tissues, where they ingest and digest foreign material and cell remnants and help orchestrate the immune response. Resident macrophages share a number of universal functions, yet transcriptional and functional diversity exists between anatomically distinct macrophage populations, indicating that the tissue microenvironment is an important factor that influences macrophage function (1,2). On page 1190 of this issue Chakarovet al.(3) identify two populations of interstitial macrophages in the lung. These macrophage subsets were not only phenotypically distinct but also showed apparent differences in their intratissue localization: One population lies close to tissue nerve bundles, whereas the other population is closely associated with blood vessels and plays an important role in maintaining blood vessel integrity and antifibrotic activity during pathology. This provides new insight into the diversity and functional dichotomy of macrophage populations even within a single tissue.
影响因子：
64.5
作者：
Gosselin D;Link VM;Romanoski CE;Fonseca GJ;Eichenfield DZ;Spann NJ;Stender JD;Chun HB;Garner H;Geissmann F;Glass CK
通讯作者：
Glass CK