INTRAHIPPOCAMPAL SEPTAL GRAFTS AMELIORATE LEARNING IMPAIRMENTS IN AGED RATS
INTRAHIPPOCAMPAL SEPTAL GRAFTS AMELIORATE LEARNING IMPAIRMENTS IN AGED RATS
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DOI：
10.1126/science.6539949
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
KELLY, PAT
中科院分区：
文献类型：
--
作者：
GAGE, FH;BJORKLUND, A;KELLY, PAT
将富含胆碱能神经元的胎儿隔组织作为游离细胞悬液植入空间学习能力严重受损的老年大鼠海马结构深处。2.5-3个月后，移植的老鼠，而不是对照组，在空间学习测试中的表现有所改善。他们的进步部分是由于在任务中使用空间线索的能力增加。在所有的动物中，移植物在周围的宿主海马结构中产生了广泛的乙酰胆碱酯酶阳性末端网络。胆碱能神经元在宿主海马电路中的移植物上的作用可能是所观察到的功能恢复的必要的，但也许不是足够的，先决条件的网站。
Grafts of fetal septal tissue rich in cholinergic neurons were implanted as a dissociated cell suspension into the depth of the hippocampal formation in aged rats with severe impairments in spatial learning abilities. After 2.5-3 mo., the rats with grafts, but not the controls, had improve their performance in a spatial learning test. Their improvement was due in part, to an increased ability to use spatial cues in the task. In all animals the grafts had produced an extensive acetylcholinesterase-positive terminal network in the surrounding host hippocampal formation. The action of cholinergic neurons in the graft onto elements in the host hippocampal circuitry may be a necessary, but perhaps not sufficient, prerequisite site for the observed functional recovery.