Rapid task-related plasticity of spectrotemporal receptive fields in primary auditory cortex
Rapid task-related plasticity of spectrotemporal receptive fields in primary auditory cortex
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DOI：
10.1038/nn1141
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发表时间：
2003-11-01
影响因子：
25
通讯作者：
Klein, D
中科院分区：
文献类型：
--
作者：
Fritz, J;Shamma, S;Klein, D
我们研究了这样的假设：任务表现可以根据特定的任务需求和显着的感觉线索快速、适应性地重塑皮质感受野特性。我们记录了行为雪貂初级听觉皮层的神经元反应，这些雪貂被训练来检测任何频率的目标音调。通过测量一系列被动和主动行为条件下每个细胞的光谱时间响应场（STRF）的焦点变化来量化皮质可塑性。 STRF 测量与任务执行同时进行，提供持续行为期间动态 STRF 的多个快照。在检测任务期间关注特定的目标频率会持续引起 STRF 形状的局部促进变化，这种变化发生得很快。这种调节变化可以增强皮质对目标音调的整体响应性，并增加在检测任务期间“捕获”关注目标的可能性。一些感受野的变化在任务结束后持续数小时，因此可能有助于长期感觉记忆。
We investigated the hypothesis that task performance can rapidly and adaptively reshape cortical receptive field properties in accord with specific task demands and salient sensory cues. We recorded neuronal responses in the primary auditory cortex of behaving ferrets that were trained to detect a target tone of any frequency. Cortical plasticity was quantified by measuring focal changes in each cell's spectrotemporal response field (STRF) in a series of passive and active behavioral conditions. STRF measurements were made simultaneously with task performance, providing multiple snapshots of the dynamic STRF during ongoing behavior. Attending to a specific target frequency during the detection task consistently induced localized facilitative changes in STRF shape, which were swift in onset. Such modulatory changes may enhance overall cortical responsiveness to the target tone and increase the likelihood of 'capturing' the attended target during the detection task. Some receptive field changes persisted for hours after the task was over and hence may contribute to long-term sensory memory.