Appendicular skeletal muscle mass: Effects of age, gender, and ethnicity
Appendicular skeletal muscle mass: Effects of age, gender, and ethnicity
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DOI：
10.1152/jappl.1997.83.1.229
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发表时间：
1997-07-01
影响因子：
3.3
通讯作者：
Heymsfield, SB
中科院分区：
文献类型：
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作者：
Gallagher, D;Visser, M;Heymsfield, SB
这项研究检验了这样的假设：在首先调整身高和体重后，老年女性和男性的骨骼肌质量会减少。通过使用双能 X 射线吸收测定法估计健康成人队列中的四肢骨骼肌质量来评估该假设。第二个目的是检验以下假设：全身 K-40 计数得出的全身钾 (TBK) 是骨骼肌质量的可靠间接测量方法。还探讨了性别（n = 148 名女性和 136 名男性）和种族（n = 152 名非裔美国人和 132 名白种人）对阑尾骨骼肌和 TBK 的独立影响。主要发现是 1) 对于四肢骨骼肌质量（总、腿和手臂）和 TBK，首先通过身高和体重的逐步多元回归进行调整后，年龄是一个独立的决定因素（多元回归模型 r(2) = 类似于 0.60）；随着年龄的增长，男性的绝对下降幅度几乎是女性的两倍；在首先调整身高、体重和年龄后，在男性和非裔美国人中观察到明显更大的绝对量；超过 80% 的性别内或族裔群体个体间成分差异是通过身高、体重、年龄、性别和种族差异来解释的； 2) 大部分个体间 TBK 变异可以通过附肢骨骼肌总量来解释 (r(2) = 0.865)，而年龄、性别和种族虽小但显着的附加协变量 (总 r(2) = 0.903)。我们的研究支持老年人骨骼肌减少的假设，并且 TBK 可以对骨骼肌质量提供合理的间接评估。这些发现为研究各种健康相关疾病中的骨骼肌质量奠定了基础。
This study tested the hypothesis that skeletal muscle mass is reduced in elderly women and men after adjustment first for stature and body weight. The hypothesis was evaluated by estimating appendicular skeletal muscle mass with dual-energy X-ray absorptiometry in a healthy adult cohort. A second purpose was to test the hypothesis that whole body K-40 counting-derived total body potassium (TBK) is a reliable indirect measure of skeletal muscle mass. The independent effects on both appendicular skeletal muscle and TBK of gender (n = 148 women and 136 men) and ethnicity (n = 152 African-Americans and 132 Caucasians) were also explored. Main findings were 1) for both appendicular skeletal muscle mass (total, leg, and arm) and TBK, age was an independent determinant after adjustment first by stepwise multiple regression for stature and weight (multiple regression model r(2) = similar to 0.60); absolute decrease with greater age in men was almost double that in women; significantly larger absolute amounts were observed in men and African-Americans after adjustment first for stature, weight, and age; and >80% of within-gender or -ethnic group between-individual component variation was explained by stature, weight, age, gender, and ethnicity differences; and 2) most of between-individual TBK variation could be explained by total appendicular skeletal muscle (r(2) = 0.865), whereas age, gender, and ethnicity were small but significant additional covariates (total r(2) = 0.903). Our study supports the hypotheses that skeletal muscle is reduced in the elderly and that TBK provides a reasonable indirect assessment of skeletal muscle mass. These findings provide a foundation for investigating skeletal muscle mass in a wide range of health-related conditions.