Significance of xenon-133 clearance rate from canine and human joints.
Significance of xenon-133 clearance rate from canine and human joints.
复制标题
犬和人类关节中氙 133 清除率的意义。
DOI：
10.1002/art.1780150407
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发表时间：
1972
影响因子：
--
通讯作者：
D. Mccarty
中科院分区：
文献类型：
--
作者：
P. Phelps;A. D. Steele;D. Mccarty
犬和人膝关节的133Xe清除率曲线有两个单指数分量。快速半间隙时间为T1/2F，慢速半间隙时间为T1/2S。测定关节周围组织133Xe浓度；T1/2S期间，核素主要分布于关节内脂肪，T1/2F期间，核素分布于滑液、滑膜和脂肪之间。由于133Xe在T1/2S和T1/2F期间的主要组织定位，T1/2S被认为代表关节脂肪的清除，而T1/2F代表滑液和膜的清除。使用氙气清除率来计算滑膜或关节脂肪的血流量需要几个假设，这些假设目前无法通过实验验证。关节内压力升高，而不是关节内容积升高，降低了两个隔室的133Xe间隙。晶体诱导的炎症通常与更快的T1/2S相关，尽管在一名志愿者中，在部分炎症渗出物被清除之前，T1/2S较慢。另一方面，T1/2F是可变的。
The clearance curve of 133Xe from canine and human knee joints has two monoexponential components. The rapid half clearance time is designated T1/2F and the slower T1/2S. 133Xe concentration in periarticular tissues was measured; the nuclide was predominately in the intraarticular fat during T1/2S and was distributed between the synovial fluid, synovial membrane and fat during T1/2F. Because of predominant tissue localization of 133Xe during T1/2S and T1/2F, T1/2S is thought to represent clearance from articular fat and T1/2F to represent clearance from synovial fluid and membrane. Use of xenon clearance to calculate the blood flow to synovium or articular fat requires several assumptions that cannot be experimentally verified at this time. Elevation of intraarticular pressure, but not intraarticular volume, decreased 133Xe clearance from both compartments. Crystal-induced inflammation was usually associated with faster T1/2S, although in one human volunteer T1/2S was slower until a part of the inflammatory exudate was removed. On the other hand, T1/2F was variable.