DAILY WALKING COMBINED WITH DIET THERAPY IS A USEFUL MEANS FOR OBESE NIDDM PATIENTS NOT ONLY TO REDUCE BODY-WEIGHT BUT ALSO TO IMPROVE INSULIN SENSITIVITY
DAILY WALKING COMBINED WITH DIET THERAPY IS A USEFUL MEANS FOR OBESE NIDDM PATIENTS NOT ONLY TO REDUCE BODY-WEIGHT BUT ALSO TO IMPROVE INSULIN SENSITIVITY
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DOI：
10.2337/diacare.18.6.775
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发表时间：
1995-06-01
期刊：
影响因子：
16.2
通讯作者：
SATO, YZ
中科院分区：
文献类型：
--
作者：
YAMANOUCHI, K;SHINOZAKI, T;SATO, YZ
目的：评估步行联合饮食治疗（1000 - 1600 kcal/天）对肥胖非胰岛素依赖型糖尿病（NIDDM）患者胰岛素敏感性的影响。研究设计与方法：将受试者分为两组：单独饮食组10例（D组），饮食加运动组14例（DE组）。DE组被要求在一个平坦的场地上行走至少10,000步/天，由计步器监测（29,200 +/- 2,100步/天），D组被要求保持正常的日常生活（4,500 +/- 290步/天）。胰岛素输注速率为40 μ m的葡萄糖钳夹手术。(2)。Min（-1）分别在6- 8周训练前后进行。平均血清胰岛素浓度在720 - 790 pmol/l之间。结果——研究期间，D组和DE组体重显著降低（P < 0.01），但DE组体重降低量大于D组（7.8 +/- 0.8 vs 4.2 +/- 0.5 kg, P < 0.01）。训练后，D组葡萄糖输注率（GIR）和代谢清除率（MCR）无显著升高；DE组GIR和MCR从17.21 +/- 1.11 μ mol显著升高至26.09 +/- 1.11 μ mol。公斤(1)。min(-1) （P < 0.001）和从3.0 +/- 0.3到5.3 +/- 0.4 ml。公斤(1)。min(-1) （P < 0.001）。方差分析显示运动对MCR的改善有显著影响（石灰X运动，P = 0.0005）。在de组中，δ MCR与日均步数之间也存在显著相关性（r = 0.7257, P < 0.005）。结论-步行安全且易于融入日常生活，可推荐作为肥胖NIDDM患者饮食治疗的辅助治疗，不仅可以降低体重，还可以改善胰岛素敏感性。
OBJECTIVE - To evaluate the effects of walking combined with diet therapy (1,000-1,600 kcal/day) on insulin sensitivity in obese non-insulin-dependent diabetes mellitus (NIDDM) patients.RESEARCH DESIGN AND METHODS - Subjects were divided into two groups: 10 patients were managed by diet alone (group D), and 14 patients were placed in the diet and exercise group (group DE). Group DE was instructed to walk at least 10,000 steps/day on a flat field as monitored by pedometer (29,200 +/- 2,100 steps/day), and group D was told to maintain a normal daily routine (4,500 +/- 290 steps/day). A glucose clamp procedure at an insulin infusion rate of 40 mU . m(-2) . min(-1) was performed before and after the 6- to 8-week training program. Mean serum insulin concentrations ranged from 720 to 790 pmol/l.RESULTS - While body weight (BW) in groups D and DE decreased significantly (P < 0.01) during the study, the amount of BW reduction in group DE was greater than that in group D (7.8 +/- 0.8 vs. 4.2 +/- 0.5 kg, P < 0.01). After training, glucose infusion rate (GIR) and metabolic clearance rate (MCR) in group D did not significantly increase; however, GIR and MCR increased significantly in group DE, from 17.21 +/- 1.11 to 26.09 +/- 1.11 mu mol . kg(-1) . min(-1) (P < 0.001) and from 3.0 +/- 0.3 to 5.3 +/- 0.4 ml . kg(-1) . min(-1) (P < 0.001), respectively. The analysis of variance showed significant effects of exercise (lime X exercise, P = 0.0005) for the improvement of MCR. Significant correlations were also observed between Delta MCR and average steps per day (r = 0.7257, P < 0.005) in group DE.CONCLUSIONS - Walking, which can be safely performed and easily incorporated into daily life, can be recommended as an adjunct therapy to diet treatment in obese NIDDM patients, not only for BW reduction, bur also for improvement of insulin sensitivity.