The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer
The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer
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DOI：
10.1007/s10620-007-9887-0
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发表时间：
2008-02-01
影响因子：
3.1
通讯作者：
Harigaya, Kenichi
中科院分区：
文献类型：
--
作者：
Takami, Yoji;Higashi, Morihiro;Harigaya, Kenichi
Rho家族gtpase在与恶性转化和转移相关的许多细胞功能的调控中发挥关键作用。为了评估这些gtpase在结直肠癌中的作用，我们分析了这些蛋白在配对的肿瘤和非肿瘤组织中的表达水平和活性。评估肿瘤组织中蛋白水平和活性与临床病理特征的关系。肿瘤组织中RhoA、活性RhoA、Rac1、活性Rac1的表达水平均高于正常组织。原发肿瘤中RhoA蛋白的活性与淋巴结转移相关。蛋白表达水平与其他临床病理结果没有关系。这些发现提示Rho家族小gtpase与结直肠癌的恶性转化和进展有关，RhoA的激活与淋巴结转移有关。
Rho family GTPases play a pivotal role in the regulation of numerous cellular functions associated with malignant transformation and metastasis. To evaluate the role of these GTPases in colorectal cancer, the protein expression levels and activities of these proteins in matched sets of tumor and non-tumor tissues of surgical specimens were analyzed. The relationship between the protein levels and activities in tumor tissues to the clinicopathological features was also assessed. The expression levels of RhoA, active RhoA, Rac1, and active Rac1 in tumor tissues were higher than in normal tissues. The amounts of active RhoA protein in primary tumors correlated with lymph nodes metastasis. No relationship was noted between the protein expression levels and other clinicopathological findings. These findings suggest that the Rho family small GTPases are related to malignant transformation and progression of colorectal cancer and the activation of RhoA is associated with the lymph node metastasis.