ELEVATION OF SERUM ALKALINE-PHOSPHATASE ACTIVITY AND RELATED ENZYMES IN DIABETES-MELLITUS
ELEVATION OF SERUM ALKALINE-PHOSPHATASE ACTIVITY AND RELATED ENZYMES IN DIABETES-MELLITUS
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DOI：
10.1016/s0009-9120(77)90116-3
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发表时间：
1977-01-01
影响因子：
2.8
通讯作者：
KNIGHT, AH
中科院分区：
文献类型：
--
作者：
GOLDBERG, DM;MARTIN, JV;KNIGHT, AH
在101例连续住院的糖尿病患者中，29例血清酶活性升高归因于公认的临床实体;其余17%的患者血清中碱性磷酸酶（AP）活性升高，15%的患者血清中天冬氨酸转氨酶（GOT）活性升高，12%的患者血清中乳酸脱氢酶（LDH）活性升高。酮症酸中毒和3个月内死亡。血清酶活性升高的患者比酶活性正常的患者更常见。一项对200名首次在门诊就诊的连续新发未经治疗的糖尿病患者的研究显示，15名患者具有临床可解释的异常血清酶活性。在其余患者中，11%的AP活性升高，12%的GOT活性升高，21%的LDH活性升高;这些患者的血糖浓度往往高于血清酶正常的受试者。这些异常似乎是糖尿病的内在特征，与病程、并发症或疾病治疗无关。它们似乎与肝脏受累无直接关系。
Of 101 consecutive hospitalized diabetic patients, 29 had elevated serum enzyme activities attributable to recognized clinical entities; 17% of the remainder had raised alkaline phosphatase (AP) activity, 15% had raised aspartate aminotransferase (GOT) activity and 12% raised lactate dehydrogenase (LDH) activity in serum. Ketoacidosis and death within 3 mo. were commoner among patients with elevated serum enzyme activities than among those with normal enzymes. A study of 200 consecutive new untreated diabetics when 1st seen at an out-patient clinic revealed 15 with clinically explainable abnormal serum enzyme activities. Of the remainder, 11% had raised AP activity, 12% raised GOT activity, and 21% raised LDH activity in serum; these patients tended to have higher blood sugar concentrations than the subjects with normal serum enzymes. These abnormalities seem to be an intrinsic feature of diabetes mellitus which do not relate to duration, complications or treatment of the disease. They do not seem to be directly related to hepatic involvement.