Kinetic Analysis of Benign and Malignant Breast Lesions With Ultrafast Dynamic Contrast-Enhanced MRI: Comparison With Standard Kinetic Assessment
Kinetic Analysis of Benign and Malignant Breast Lesions With Ultrafast Dynamic Contrast-Enhanced MRI: Comparison With Standard Kinetic Assessment
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DOI：
10.2214/ajr.15.15957
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发表时间：
2016-11-01
影响因子：
5
通讯作者：
Karczmar, Gregory S.
中科院分区：
文献类型：
--
作者：
Abe, Hiroyuki;Mori, Naoko;Karczmar, Gregory S.
客观的。这项研究的目的是评估用超快MRI获取和标准获取测量的诊断参数，并比较诊断效用，以将良性与恶性病变区分开。材料和方法。超快采集是一种用于获得3D全胸图像的高分辨率（7秒）成像技术。动态对比增强的3-T MRI协议由一个未增强的标准和超快采集组成，其中包括八个对比度增强的超快图像和四个标准图像。对60例患有33例恶性肿瘤和29个良性病变的患者进行了回顾性评估。使用计算机辅助检测系统来通过鉴定体素显示出在标准成像的第一阶段显示最高信号强度的素来获得初始增强率和信号增强率（SER）。从相同的体素中，获得了超快采集的每个时间点的增强速率，以及从零到每个时间点的动力学曲线的AUC。良性和恶性病变在增强率和动力学AUC方面存在统计学上的显着差异，以及用于标准成像的初始增强率和SER的统计差异。 ROC分析表明，在超快成像中的增强率与SER或标准成像中的初始增强率之间没有显着差异。超快成像可用于区分良性与恶性病变。超快成像的差异效用与较短的研究时间中的标准动力学评估相当。
OBJECTIVE. The purposes of this study were to evaluate diagnostic parameters measured with ultrafast MRI acquisition and with standard acquisition and to compare diagnostic utility for differentiating benign from malignant lesions.MATERIALS AND METHODS. Ultrafast acquisition is a high-temporal-resolution (7 seconds) imaging technique for obtaining 3D whole-breast images. The dynamic contrast-enhanced 3-T MRI protocol consists of an unenhanced standard and an ultrafast acquisition that includes eight contrast-enhanced ultrafast images and four standard images. Retrospective assessment was performed for 60 patients with 33 malignant and 29 benign lesions. A computeraided detection system was used to obtain initial enhancement rate and signal enhancement ratio (SER) by means of identification of a voxel showing the highest signal intensity in the first phase of standard imaging. From the same voxel, the enhancement rate at each time point of the ultrafast acquisition and the AUC of the kinetic curve from zero to each time point of ultrafast imaging were obtained.RESULTS. There was a statistically significant difference between benign and malignant lesions in enhancement rate and kinetic AUC for ultrafast imaging and also in initial enhancement rate and SER for standard imaging. ROC analysis showed no significant differences between enhancement rate in ultrafast imaging and SER or initial enhancement rate in standard imaging.CONCLUSION. Ultrafast imaging is useful for discriminating benign from malignant lesions. The differential utility of ultrafast imaging is comparable to that of standard kinetic assessment in a shorter study time.