Response characteristics of basolateral and centromedial neurons in the primate amygdala.
Response characteristics of basolateral and centromedial neurons in the primate amygdala.
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DOI：
10.1523/jneurosci.3225-10.2010
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发表时间：
2010-12-01
期刊：
影响因子：
--
通讯作者：
Gothard KM
中科院分区：
文献类型：
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作者：
Mosher CP;Zimmerman PE;Gothard KM
基于细胞结构和连接，灵长类动物杏仁核的主要核团分为两个集群：基底外侧（BL）和中央内侧（CM）。这些解剖学特征表明核团之间存在功能分工。BL核被认为主要参与评估所有刺激的情感意义或上下文相关性，包括面部表情等社交信号。CM核似乎参与分配注意力的刺激，高的意义，并在启动情况下适当的自主反应。本研究的目的是确定这种分工如何体现在这两个核群记录的神经元的反应特性中。我们记录了454个单个神经元的活动，这些神经元来自三只训练执行图像查看任务的猴子的已识别核位点。这项任务需要定向和注意预测试验进展的线索，并观看具有广泛变化的情感内容的图像。这两个神经元群体的神经生理特性表现出很大的重叠。然而，我们发现，CM神经元比BL神经元表现出更高的放电和更不规则的尖峰模式。此外，CM核中的神经元更可能对任务事件（固定，图像打开，图像关闭）做出反应，而BL核中的神经元更可能选择性地对刺激图像的内容做出反应。CM和BL神经元的生理特性的重叠表明跨核群的分布式处理。因此，这些差异似乎是一种加工偏差，而不是相互排斥功能的标志。
Based on cellular architecture and connectivity, the main nuclei of the primate amygdala are divided in two clusters: basolateral (BL) and centromedial (CM). These anatomical features suggest a functional division of labor among the nuclei. The BL nuclei are thought to be involved primarily in evaluating the emotional significance or context-dependent relevance of all stimuli, including social signals such as facial expressions. The CM nuclei appear to be involved in allocating attention to stimuli of high significance and in initiating situation-appropriate autonomic responses. The goal of this study was to determine how this division of labor manifests in the response properties of neurons recorded from these two nuclear groups. We recorded the activity of 454 single neurons from identified nuclear sites in three monkeys trained to perform an image viewing task. The task required orienting and attending to cues that predicted trial progression and viewing images with broadly varying emotional content. The two populations of neurons showed large overlaps in neurophysiological properties. We found, however, that CM neurons show higher firing and less regular spiking patterns than BL neurons. Furthermore, neurons in the CM nuclei were more likely to respond to task events (fixation, image-on, image-off), while neurons in the BL nuclei were more likely to respond selectively to the content of stimulus images. The overlap in the physiological properties of the CM and BL neurons suggest distributed processing across the nuclear groups. The differences, therefore, appear to be a processing bias rather than a hallmark of mutually exclusive functions.