Lacrimal System Obstruction After Radioiodine Therapy in Differentiated Thyroid Carcinomas: A Prospective Comparative Study.
Lacrimal System Obstruction After Radioiodine Therapy in Differentiated Thyroid Carcinomas: A Prospective Comparative Study.
复制标题
分化型甲状腺癌放射性碘治疗后泪道系统阻塞：一项前瞻性比较研究。
作者：
F. L. da Fonseca;P. K. Yamanaka;Juliana Mika Kato;S. Matayoshi
背景
放射性碘治疗（RIT）是分化型甲状腺癌的一种既定治疗方法，鉴于这种恶性肿瘤发病率的不断增加，在世界各地广泛使用。尽管严重的不良反应并不常见，但已有口干、唾液腺炎和吞咽困难等并发症的报道。尽管有干眼、角膜结膜炎和泪道系统阻塞（LSO）的报道，特别是在高累积剂量的放射性药物之后，但眼睛和辅助视觉结构的受累并不常见。 LSO 的发生率尚未明确。
目标
本研究的目的是确定接受 RIT 的患者在治疗后 2、4、6 和 12 个月时发生 LSO 的频率。
方法
对接受（第 1 组）和未接受（第 2 组）RIT 的分化型甲状腺癌患者在术前和术后以及术后 2、4、6 和 12 个月或 RIT 后进行评估。患者接受泪膜评估以及泪道系统探查和冲洗。
结果
第 1 组（n = 44；88 只眼）包含 3 名患有 LSO 的患者（4 只眼），对应的发生率为 4.55%（88 只眼中的 4 例事件）或 6.8%（44 名患者中的 3 例）。第 2 组（n = 43；86 只眼睛）没有出现任何 LSO 病例。
结论
在这项研究中，一项积极的前瞻性调查允许在 RIT 后的前六个月内检测到 LSO。这一发现表明了向患者和卫生专业人员明确这种关联的重要性，以实现早期诊断、适当治疗和预防 LSO 相关并发症。
BACKGROUND
Radioiodine therapy (RIT) is an established treatment for differentiated thyroid carcinomas, and is widely used throughout the world, given the increasing incidence of this malignancy. Although serious adverse effects are infrequent, complications such as dry mouth, sialadenitis, and dysphagia have been described. The involvement of the eyes and accessory visual structures is not commonly discussed, despite dry eye, keratoconjunctivitis, and lacrimal system obstruction (LSO) being reported, especially after high cumulative doses of radiopharmaceuticals. The incidence of LSO is not well established.
OBJECTIVES
The aim of this study was to determine the frequency of LSO in patients undergoing RIT at 2, 4, 6, and 12 months after treatment.
METHODS
Patients with differentiated thyroid carcinoma undergoing (group 1) and not undergoing (group 2) RIT were evaluated in the preoperative and postoperative periods and 2, 4, 6, and 12 months post surgery or post RIT. Patients underwent tear film evaluation and lacrimal system probing and irrigation.
RESULTS
Group 1 (n = 44; 88 eyes) contained three patients (four eyes) with LSO, corresponding to an incidence of 4.55% (four events in 88 eyes) or 6.8% (three cases in 44 patients). Group 2 (n = 43; 86 eyes) did not present any cases of LSO.
CONCLUSIONS
In this study, an active prospective investigation allowed LSO detection during the first six months after RIT. This finding demonstrates the importance of making this association clear to patients and health professionals, with a view to early diagnosis, appropriate treatment, and preventing LSO-related complications.
影响因子：
13.5
作者：
Kogai, Takahiko;Brent, Gregory A.
通讯作者：
Brent, Gregory A.
影响因子：
6.6
作者：
Jonklaas, Jacqueline
通讯作者：
Jonklaas, Jacqueline