Himeic acid A:: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp.
Himeic acid A:: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp.
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DOI：
10.1016/j.bmcl.2004.10.012
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发表时间：
2005-01-03
影响因子：
2.7
通讯作者：
Yokosawa, H
中科院分区：
文献类型：
--
作者：
Tsukamoto, S;Hirota, H;Yokosawa, H
从海洋来源的真菌曲霉培养物中分离出一种新的泛素激活酶 (E1) 抑制剂，即喜马酸 A。通过光谱分析确定结构。 E1-泛素 (Ub) 中间体的形成在浓度为 50 μM 时被血红酸 A 抑制 65%，而两种新的相关化合物血红酸 B 和 C，即使在浓度为 100 μM 时也几乎没有显示出抑制活性。 (C) 2004 Elsevier Ltd. 保留所有权利。
A new ubiquitin-activating enzyme (E1) inhibitor, himeic acid A, was isolated from a culture of marine-derived fungus, Aspergillus sp. The structure was determined by spectroscopic analysis. The formation of an E1-ubiquitin (Ub) intermediate was 65% inhibited by himeic acid A at the concentration of 50 muM, while two new related compounds, himeic acids B and C, showed little inhibitory activity even at 100 muM. (C) 2004 Elsevier Ltd. All rights reserved.