Breast abnormalities in patients with cystic fibrosis: previously unrecognized changes.
Breast abnormalities in patients with cystic fibrosis: previously unrecognized changes.
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DOI：
10.1016/s1092-9134(98)80019-1
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发表时间：
1998-10-01
影响因子：
2
通讯作者：
Holsclaw, D S Jr
中科院分区：
文献类型：
--
作者：
Garcia, F U;Galindo, L M;Holsclaw, D S Jr
我们回顾了19名青春期后女性和3名青春期前囊性纤维化患者的乳腺组织，以确定存在的组织病理学变化。尸检材料可从19名死于囊性纤维化并发症的患者中获得。2例患者因乳腺癌行肿块切除术，另1例患者因乳腺癌行乳腺活检和双侧预防性乳房切除术。青春期后患者的年龄范围为18至50岁（中位年龄为32岁）。囊性纤维化女性患者乳房的组织学变化尚未得到充分研究，唯一的病例报告表明，这些患者患有完全小叶发育不全。这项研究表明，青春期后的乳房有正常的发展和不同程度的纤维化影响小叶单位和导管，增殖病变和癌可能会遇到。
We reviewed breast tissue from 19 female postpubertal and three prepubertal patients with cystic fibrosis to determine the histopathologic changes present. Autopsy material was available from 19 patients who died from complications of cystic fibrosis. Two patients had lumpectomies for breast carcinoma and an additional patient had a breast biopsy and bilateral prophylactic mastectomies for breast carcinoma. The postpubertal patients ranged in age from 18 to 50 years (median age, 32 years). The histologic changes in the breast of female patients with cystic fibrosis have not been fully studied, and the only case reported suggests that these patients suffered from complete lobular agenesis. This study shows that postpubertal breasts had normal development and varying degrees of fibrosis affecting lobular units and ducts, and that proliferative lesions and carcinoma could be encountered.