Myomelanocytic tumor of the thigh.
Myomelanocytic tumor of the thigh.
复制标题
大腿肌黑细胞瘤。
DOI：
10.1097/00000478-200309000-00019
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
M. Colecchia
中科院分区：
文献类型：
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作者：
J. Diment;M. Colecchia
这一具有里程碑意义的研究p16 INK 4a描绘宫颈上皮瘤变是一个重大的进步，其替代有效性是令人信服的。1考虑到这一点，修订较低解释门槛的标准可能是有益的。图1C和D显示局灶性阳性（指定为阴性），可能仍有替代值;图4 B和图3B（指定为阳性）在较小程度上也有局灶性阳性区域，毗邻免疫组织化学染色的较密集区域。局灶性阳性可能代表进化的遗传不稳定性在所有四个插图。假设排除了有效的假阳性染色，因此即使是轻微的阳性也可能值得阳性阅读。这样的修改可能会更明确地定义反应性与CIN 1基团，这是这项令人钦佩的工作的主要推动力。它可以通过消除“不清楚”类别、提高“正常”的一致性（94%）以及使CIN 1的一致性（91%）更接近于CIN 2的一致性水平（100%）来简化后续研究。
This landmark study of p16INK4a delineation of cervical epithelial neoplasia is a major advance; its surrogate validity is convincing. 1With this in mind, revision of criteria for the lower threshold of interpretation may be useful. Figures 1C and D show focal positivity (designated as negative) and may still have surrogate value; Figure 4B and, to a lesser extent, Figure 3B (designated as positive) also have focal areas of positivity adjoining denser areas of immunohistochemical staining. Focal positivity may represent evolving genetic instability in all four illustrations. Assuming that valid false-positive staining is excluded, even slight positivity may therefore merit a positive reading. Such a modification may more sharply define reactive versus CIN 1 groups, the major thrust of this admirable work. It may streamline followup studies by eliminating the “unclear” category, by improving the concordance of “normal”(94%), and by bringing the concordance of CIN 1 (91%) closer to the concordance level of CIN 2 (100%).