Urinary biomarkers for the early diagnosis of retinopathy and nephropathy in type 1 diabetes mellitus: a "steady stream" of information using proteomics.
Urinary biomarkers for the early diagnosis of retinopathy and nephropathy in type 1 diabetes mellitus: a "steady stream" of information using proteomics.
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DOI：
10.1016/j.trsl.2013.11.013
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Evans-Molina C
中科院分区：
文献类型：
--
作者：
Sims EK;Evans-Molina C
1 型糖尿病 (T1D) 是由胰腺 β 细胞的自身免疫性破坏引起的，导致胰岛素绝对缺乏和慢性高血糖。 1 T1D 在美国影响着近 300 万人，并且由于尚不清楚的原因，全球发病率以每年约 3% 的速度增加。 2 T1D 目前是美国青少年中第三常见的慢性健康疾病，估计每年产生的费用超过 140 亿美元，其中大部分费用与治疗大血管和微血管疾病相关并发症的费用有关。 3微血管糖尿病并发症，包括视网膜病变、肾病和神经病变，是由于小血管损伤而发生的，是长期 T1D 最具破坏性的后果之一。 4 糖尿病视网膜病变 (DR) 是由于内皮功能障碍、炎症、氧化应激、缺氧和晚期糖基化终产物信号转导继发的视网膜和神经胶质细胞损伤所致。最先进的视网膜病变形式被描述为增殖性 DR，其特征是视网膜内新生血管形成，这些新形成但结构不完善的血管会渗漏和出血。 DR 是 20 岁至 74 岁人群失明的主要原因。 4, 5 糖尿病肾病 (DN) 同样具有破坏性，是美国终末期肾病的最常见原因。 DN 是由肾微脉管系统和肾小球内的结构变化引起的。这些变化包括细胞外基质和基底膜的扩张、系膜增厚以及继发于肾小球毛细血管压力增加和肾素-血管紧张素-醛固酮系统激活以及其他炎症而发生的纤维化。
Type 1 diabetes mellitus (T1D) results from autoimmune destruction of the pancreatic β cell, leading to absolute insulin deficiency and chronic hyperglycemia. 1 T1D affects nearly 3 million individuals in the United States and, for reasons that remain unclear, the worldwide incidence is increasing at a rate of approximately 3% per year. 2 Currently the third most common chronic health condition among American youth, T1D generates an estimated annual cost of more than $14 billion, with much of this cost related to the expense of caring for macrovascular and microvascular disease-related complications. 3Microvascular diabetic complications, including retinopathy, nephropathy, and neuropathy, occur as a result of damage to small blood vessels and are among the most devastating consequences of longstanding T1D. 4 Diabetic retinopathy (DR) arises from damage to the retinal and glial cells that occurs secondary to endothelial dysfunction, inflammation, oxidative stress, hypoxia, and signaling through advanced glycation end products. The most advanced form of retinopathy is described as proliferative DR and is characterized by neovascularization within the retina, with leakage and hemorrhage from these newly formed but structurally inadequate vessels. DR is the leading cause of blindness in persons between the ages of 20 years and 74 years. 4, 5 Diabetic nephropathy (DN) is equally devastating and ranks as the most common cause of end-stage renal disease in the United States. DN results from structural changes within the renal microvasculature and glomeruli. These changes include expansion of the extracellular matrix and basement membrane, mesangial thickening, and fibrosis that occur secondary to increased glomerular capillary pressure and activation of the renin-angiotensin-aldosterone system as well as other inflammatory
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影响因子：
3.3
作者：
Konig, Manige;Lamos, Elizabeth Mary;Davis, Stephen N.
通讯作者：
Davis, Stephen N.
影响因子：
--
作者：
Chedid, Erica H;Golden, Quin R;Jager, Rama D
通讯作者：
Jager, Rama D
影响因子：
2.8
作者：
Lokamani, Ilambarthi;Looi, Mee-Lee;Jamal, Rahman
通讯作者：
Jamal, Rahman
影响因子：
3.7
作者：
Argilés Á;Siwy J;Duranton F;Gayrard N;Dakna M;Lundin U;Osaba L;Delles C;Mourad G;Weinberger KM;Mischak H
通讯作者：
Mischak H
DOI：
10.1136/bmj.b4909
发表时间：
2010-01-08
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Bonds DE;Miller ME;Bergenstal RM;Buse JB;Byington RP;Cutler JA;Dudl RJ;Ismail-Beigi F;Kimel AR;Hoogwerf B;Horowitz KR;Savage PJ;Seaquist ER;Simmons DL;Sivitz WI;Speril-Hillen JM;Sweeney ME
通讯作者：
Sweeney ME