CEREBRAL MALARIA IN INBRED MICE .1. A NEW MODEL AND ITS PATHOLOGY
CEREBRAL MALARIA IN INBRED MICE .1. A NEW MODEL AND ITS PATHOLOGY
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DOI：
10.1016/0035-9203(82)90203-6
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发表时间：
1982-01-01
影响因子：
2.2
通讯作者：
REST, JR
中科院分区：
文献类型：
--
作者：
REST, JR
在近交系小鼠品系A、A2 G、A/J、C57 L、SJL/J和SWR中测试伯氏疟原虫ANKA作为脑型疟疾模型的有用性。在A或A/J品系小鼠中获得合适的模型。5 - 8天后死亡率为100%，最终发生脑出血。描述了组织病理学。该模型在以5至7天的间隔进行6次血液传代后稳定。氯喹消除了出血，未检测到并发病毒或血液原虫感染。
Plasmodium bergheiANKA was tested for its usefulness as a model for cerebral malaria in inbred mouse strains A, A2G, A/J, C57L, SJL/J and SWR. A suitable model was obtained in A or A/J strain mice. Mortality was 100% after five to eight days with brain haemorrhages occurring terminally. The histopathology is described. The model was stable after six blood passages at 5- to 7-day intervals. Chloroquine abolished the haemorrhages and no intercurrent viral or blood protozoal infections were detected.