Topographic Variation and Interocular Symmetry of Macular Choroidal Thickness Using Enhanced Depth Imaging Optical Coherence Tomography
Topographic Variation and Interocular Symmetry of Macular Choroidal Thickness Using Enhanced Depth Imaging Optical Coherence Tomography
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DOI：
10.1167/iovs.11-8771
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发表时间：
2012-02-01
影响因子：
4.4
通讯作者：
Da Cruz, Lyndon
中科院分区：
文献类型：
--
作者：
Chen, Fred K.;Yeoh, Jonathan;Da Cruz, Lyndon
目的。方法：对50名健康成人100只眼进行了视力和眼轴长度测量，并进行了光学相干断层扫描(OCT)和增强深度成像(EDI)。手动测量中心凹和鼻侧、颞侧、中心凹上方和下方3 mm处的CTS。分析CT的地形图变异、眼间相对差异及CT的预测因素。结果：右眼和左眼的平均中心凹CT分别为334(95)和333(90)µm。对于黄斑中心凹CT，双眼之间高度相关(r=0.90)，相对眼间一致性范围为-80~+83，中位数(范围)绝对值相差21(0.4~135)。眼间CT的相对差和绝对差无显著差异。眼轴长度是预测鼻腔和中心凹CT的主要因素。眼轴长度<23.50 mm者，CT在水平和垂直子午线上对称(P<；0.05)。结论：眼间CT无明显差异。轴向长度对CT的某些变化有贡献，但对CT轮廓有很大影响。虽然眼球间的相对差异并不显著，但CT的绝对眼间差异可能达到85微米。2012年；53：975-985)doi：10.1167/iovs.11-8771
PURPOSE. To report and analyze factors influencing topographical and interocular variations in choroidal thickness (CT) in a healthy adult population.METHODS. One hundred eyes of 50 healthy subjects underwent visual acuity and axial length measurements and optical coherence tomography (OCT) with enhanced depth imaging (EDI). CTs at the fovea and at 3 mm nasal, temporal, superior, and inferior to the fovea were measured manually. Topographic variation, relative interocular differences in CT and predictors of CT were analyzed. The relationships between interocular differences in CT and differences in age and interocular axial length were explored.RESULTS. The mean (SD) foveal CT in the right and left eyes were 334 (95) and 333 (90) mu m, respectively. For foveal CT, there was a high correlation between the two eyes (r = 0.90) with a relative interocular 95% limits of agreement of -80 to +83, and a median (range) absolute difference of 21 (0.4-135). There was no significant variation in the relative and absolute interocular differences in CT. Axial length was the main predictor of CT for nasal and foveal CT. Symmetry in CT in the horizontal and vertical meridians was seen in eyes with axial length shorter than 23.50 mm (P < 0.05).CONCLUSIONS. There was no significant relative interocular difference in CT. Axial length contributes to some of the variances in CT but has a significant influence on the CT profile. Although relative interocular difference is not significant, absolute interocular differences in CT may reach 85 mu m. (Invest Ophthalmol Vis Sci. 2012;53:975-985) DOI:10.1167/iovs.11-8771