Conjugates, Complexes, and Interlocked Systems Based on Squaraines and Cyanines
Conjugates, Complexes, and Interlocked Systems Based on Squaraines and Cyanines
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DOI：
10.1007/978-3-642-04701-5_5
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Terpetschnig, Ewald A.
中科院分区：
文献类型：
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作者：
Patsenker, Leonid D.;Tatarets, Anatoliy L.;Terpetschnig, Ewald A.
本章总结了红、近红外荧光探针和标记的最新进展，这些探针和标记是基于包裹在大环内的菁氨酸和方氨酸染料，以及嵌入或结合在蛋白质、适体、树状大分子和微或纳米颗粒上的。将这些染料与另一种大分子载体或宿主分子结合可能对以下一种或多种光谱和光物理性质产生积极影响：水溶性，亮度，荧光寿命，以及化学和光稳定性，这在基于荧光的生物医学应用，药物研究和临床诊断方面具有巨大潜力。一般来说，这些组合物的性质强烈依赖于染料分子的类型以及宿主或载体大分子的性质。
This chapter summarizes recent developments of red and near infrared fluorescent probes and labels based on cyanine and squaraine dyes encapsulated in macrocycles, and embedded in or bound to proteins, aptamers, dendrimers, and micro- or nano-particles. Combining these dyes with another macromolecular carrier- or host-molecule may have a positive impact on one or more of the following spectral and photophysical properties: water-solubility, brightness, fluorescence lifetimes, as well as chemo- and photostability, which promises great potential for fluorescence-based biomedical applications, pharmaceutical research, and clinical diagnostics. In general, the resulting properties of these compositions are strongly dependent on the type of dye molecule as well as the nature of the host or carrier macromolecule.