Amyloid-related serum protein SAA in endotoxin-induced amyloidosis of the mink
Amyloid-related serum protein SAA in endotoxin-induced amyloidosis of the mink
复制标题
淀粉样蛋白相关血清蛋白SAA在内毒素诱导的水貂淀粉样变性中的作用
DOI：
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发表时间：
1976
影响因子：
15.3
通讯作者：
G. Husby
中科院分区：
文献类型：
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作者：
R. Anders;K. Nordstoga;J. Natvig;G. Husby
内毒素注射后水貂、小鼠、家兔和人血清中淀粉样蛋白aa相关蛋白（SAA）浓度均显著升高。在水貂内毒素引起的淀粉样变的发展过程中，对其进行了特别的研究。在第一次内毒素注射后24小时，所有水貂的SAA蛋白水平均显著升高，但在4周左右淀粉样变性发病前，SAA蛋白水平已降至相对较低水平。这些结果与SAA是淀粉样纤维蛋白AA的循环前体一致。然而，这两种蛋白质都可以由一个共同的前体水解而来。
The concentration of the amyloid AA-related serum protein (SAA) was markedly increased after endotoxin injections in mink, mouse, rabbit, and man. It was particularly studied during the development of endotoxin-induced amyloidosis of the mink. Protein SAA was markedly elevated in all mink 24 h after the first endotoxin injection but had fallen to relatively low levels before the onset of amyloidosis at about 4 wk. These results are consistent with SAA being a circulating precursor of the amyloid fibril protein, AA. However, both proteins may be derived by proteolysis from a common precursor.