Effects of statin treatment on uric acid homeostasis in patients with primary hyperlipidemia
Effects of statin treatment on uric acid homeostasis in patients with primary hyperlipidemia
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DOI：
10.1016/j.ahj.2004.04.005
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发表时间：
2004-10-01
影响因子：
4.8
通讯作者：
Elisaf, MS
中科院分区：
文献类型：
--
作者：
Milionis, HJ;Kakafika, AI;Elisaf, MS
背景流行病学研究表明，血清尿酸是冠状动脉疾病的危险因素。除了非诺贝特，有一些证据表明阿托伐他汀可能具有低尿酸血症作用，但其潜在机制仍有待推测。方法采用随机对照试验，观察阿托伐他汀和辛伐他汀对原发性高脂血症患者尿酸稳态的影响。共有180名患者入选；患者被随机分配到阿托伐他汀或辛伐他汀40 mg/d。结果基线血尿酸水平与体重指数、血清胰岛素、肌酐、甘油三酯水平呈正相关，与血清高密度脂蛋白水平呈负相关。两种他汀类药物均有良好的降脂作用，并显著降低纤维蛋白原和高敏C反应蛋白水平。但仅阿托伐他汀能降低血尿酸水平(从5.6±1.7 mg/dL降至4.9±1.5 mg/dL，P
Background Epidemiologic studies have shown that serum uric acid is a risk factor of coronary artery disease. in addition to fenofibrate, there is some evidence that atorvastatin may have a hypouricemic action, but the underlying mechanisms remain speculative.Methods This randomized trial was conducted to investigate the effects of atorvastatin and simvastatin on uric acid homeostasis in patients treated for primary hyperlipidemia. A total of 180 patients were enrolled; patients were randomly assigned to 40 mg/d of either atorvastatin or simvastatin. Serum lipid and metabolic parameters were measured at baseline and at 6 and 12 weeks of treatment; random urine samples were simultaneously obtained for creatinine, sodium, and uric acid determinations.Results Baseline serum uric acid levels correlated positively with the body mass index, serum insulin, creatinine, and triglyceride levels and inversely with serum HDL cholesterol levels. Both statins caused a favorable effect on lipids and a significant decrease in fibrinogen and high-sensitivity CRP levels. However, only atorvastatin reduced serum uric acid levels (from 5.6 +/- 1.7 to 4.9 +/- 1.5 mg/dL, P