Quantification of temperature and injury response in thermal therapy and cryosurgery.
Quantification of temperature and injury response in thermal therapy and cryosurgery.
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DOI：
10.1615/critrevbiomedeng.v31.i56.10
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发表时间：
2003-01-01
影响因子：
--
通讯作者：
Bischof, John C
中科院分区：
文献类型：
--
作者：
He, Xiaoming;Bischof, John C
热疗（使用能量源（射频、微波、高强度聚焦超声或激光能量）加热病理组织）和冷冻手术（使用液态或气态冷冻剂冷冻病理组织）的研究可分为两大类：基础科学和临床应用。热疗和冷冻治疗的基础科学是涉及生物学和工程学的跨学科研究领域。生物学角度的研究主要集中在大分子、细胞和组织（体外和体内）水平上确定热致损伤机制。从工程角度的研究强调如何使用工程工具来测量和预测热和损伤行为。本文将从生物学和工程学的角度详细概述与热疗和冷冻外科基础科学相关的研究。这包括热疗/冷冻手术期间和之后细胞和血管变化的实验观察，以及使用数学模型对热历史和相应损伤的量化。
Research on thermal therapy--the heating of pathological tissue using energy source (radiofrequency, microwave, high-intensity focused ultrasound, or laser energy)--and cryosurgery--the freezing of pathological tissue using either liquid or gaseous cryogens--can be classified into two broad categories: basic science and clinical application. The basic science of thermal therapy and cryosurgery is an interdisciplinary research field involving both biology and engineering. Studies from the perspective of biology mainly focus on determining the thermally induced injury mechanisms at the macromolecular, cellular, and tissue (in vitro and in vivo) levels. Studies from the engineering perspective emphasize how to measure and predict the thermal and injury behavior using engineering tools. This article will give a detailed overview of studies relevant to the basic science of thermal therapy and cryosurgery from both the biology and engineering points of view. This includes the experimental observations of cellular and vascular alterations during and after thermal therapy/cryosurgery and the quantification of thermal histories and corresponding injuries using mathematical models.