CHRONIC ULTRAVIOLET-B RADIATION-INDUCED BIOCHEMICAL-CHANGES IN THE SKIN OF HAIRLESS MICE
CHRONIC ULTRAVIOLET-B RADIATION-INDUCED BIOCHEMICAL-CHANGES IN THE SKIN OF HAIRLESS MICE
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DOI：
10.1111/j.1751-1097.1990.tb01688.x
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发表时间：
1990-01-01
影响因子：
3.3
通讯作者：
BISSETT, DL
中科院分区：
文献类型：
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作者：
CHATTERJEE, R;BENZINGER, MJ;BISSETT, DL
Skh:HR-1 无毛小鼠接受亚红斑剂量的 UVB 辐射长期照射，并在照射 6、12、18 和 24 周后测定皮肤的许多生化参数。测量的参数是水、胶原蛋白、弹性蛋白和糖胺聚糖含量；胶原酶和弹性蛋白酶水平；和 Bz-Tyr-OEt（N-苯甲酰基-L-酪氨酸乙酯）和 BAPNA（α-N-苯甲酰基-DL-精氨酸-对硝基苯胺）水解活性。将暴露于 UVB 辐射的小鼠和按时间顺序年龄匹配的对照小鼠的数据与单位面积和单位皮肤质量进行比较。在皮肤单位面积的基础上，UVB 辐射暴露增加了大多数参数的水平。特殊的例外是胶原蛋白和胶原酶，它们保持不变。以大量皮肤为基础。然而，由于其他皮肤成分的增加，胶原蛋白含量明显减少。这表明暴露于 UVB 辐射的皮肤中没有足够的胶原蛋白来支持不断增加的组织质量。
Skh:HR-1 hairless mice were irradiated chronically with sub-erythemal doses of UVB radiation, and a number of biochemical parameters in the skin were determined after 6, 12, 18, and 24 wk of exposure. The parameters measured were water, collagen, elastin, and glycosaminoglycan content; collagenase and elastase levels; and Bz-Tyr-OEt (N-benzoyl-L-tyrosine ethyl ester) and BAPNA (alpha-N-benzoyl-DL-arginine-p-nitroanilide) hydrolzying activities. Data for UVB radiation-exposed and chronological age-matched control mice were compared with respect to unit area and to unit mass of skin. On a unit area of skin basis, UVB radiation exposure increased the level of most parameters. The particular exceptions were collagen and collagenase which remained constant. On a mass of skin basis. though, there is an apparent decrease in collagen content because of the increase in the other skin components. This suggests that there is insufficient collagen in UVB radiation-exposed skin to support the increasing mass of the tissue.