Improved efficiency of photo-induced synthetic reactions enabled by advanced photo flow technologies
Improved efficiency of photo-induced synthetic reactions enabled by advanced photo flow technologies
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先进的光流技术提高了光诱导合成反应的效率
DOI：
10.1007/s43630-021-00151-6
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Ryu Ilhyong
中科院分区：
文献类型：
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作者：
Fukuyama Takahide;Kasakado Takayoshi;Hyodo Mamoru;Ryu Ilhyong
在这篇文章中，我们讨论了如何有效的光诱导有机反应时，通过我们在过去二十年的经验，不断发展的光流技术应用。我们从传统的[2 + 2]环加成的流动更新开始，使用MikroxidDwell装置作为流动反应器和紧凑的光源，如黑光灯，而不是高压汞灯。然后，我们研究了巴顿亚硝酸盐反应使用的光流动反应器组成的不锈钢通道和石英玻璃顶部由DNS提供。再次使用黑光灯是成功的。然而，通过使用LED灯，这些反应的能量分布得到了进一步改善。我们使用的光流装置，由不锈钢雕刻的微通道覆盖的石英顶部（MiChS L-1）和钠灯，异构化的fullavoid PCBM。当使用相同的光流反应器和白色LED代替间歇反应器时，光氧化还原催化的烯烃烷基化在缩短的反应时间内进行。光诱导还原5-exo-dig自由基环化反应和烯基卤的还原反应，由于光流动反应器和低压汞灯的组合顺利进行。我们还将流动技术应用于C-H键的光溴化和氯化。采用高功率LED照射时，分子氧对苯甲醇的光催化氧化变得更快。图形摘要
In this article, we discuss how effective photo-induced organic reactions became when applied evolving photo flow technologies through our experiences over these two last decades. We started with the flow update of traditional [2 + 2] cycloaddition using Mikroglas Dwell device as a flow reactor and a compact light source, such as blacklight, instead of a high-pressure mercury lamp. Then we examined Barton nitrite reaction using a photo flow reactor consisting of stainless-steel channels and a quartz glass top provided by DNS. Again the use of blacklight was successful. However, the energy profile of these reactions was improved further by the use of LED lights. We used a photo-flow set-up, consisting of stainless steel engraved microchannels covered by a quartz top (MiChS L-1) and a sodium lamp, for the isomerization of a fulleroid to PCBM. Photo-redox-catalyzed alkene alkylation proceeded within a shortened reaction time when the same photo flow reactor and white LED were used instead of a batch reactor. Photo-induced reductive 5-exo-dig radical cyclization and reduction of alkenyl halides proceeded smoothly, thanks to the combination of a photo flow reactor and low-pressure Hg lamp. We also applied flow technologies for photo-bromination and chlorination of C–H bonds. Photocatalytic oxidation of benzyl alcohol by molecular oxygen became quick when high-power LED irradiation was employed.Graphical abstract