Attitudes of Members of Genetics Professional Societies Toward Human Gene Editing
Attitudes of Members of Genetics Professional Societies Toward Human Gene Editing
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DOI：
10.1089/crispr.2019.0020
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发表时间：
2019-10-01
期刊：
影响因子：
3.7
通讯作者：
Ormond, Kelly E.
中科院分区：
文献类型：
--
作者：
Armsby, Alyssa J.;Bombard, Yvonne;Ormond, Kelly E.
基因编辑技术在易用性、效率和精确性方面都有了改进。尽管围绕人类基因编辑的可接受用途进行了讨论，但关于遗传学训练的个人观点的数据有限。2017年，我们发布了一项匿名在线调查，以评估遗传学专业协会成员对基因编辑的态度（N = 500）。几乎所有受访者都支持在非生殖性人类细胞的基础科学（99.2%）和临床（87.4%）研究中进行体细胞编辑。只有57.2%的人支持生殖系编辑基础科学研究; 31.9%的人支持将可行的胚胎移植给人类进行临床研究。虽然大多数人赞成体细胞（96.6%）和生殖系（77.8%）编辑的未来治疗用途，但几乎没有人支持体细胞（13.0%）或生殖系（8.6%）细胞的增强。这项研究描述了全球遗传学专业人士对基因编辑的态度，并有助于该领域的持续话语和政策指导。
Gene-editing technologies have improved in ease, efficiency, and precision. Although discussions are occurring around acceptable uses of human gene editing, limited data exist on the views of genetics-trained individuals. In 2017, we distributed an anonymous online survey to assess the attitudes of members of genetics professional societies toward gene editing (N = 500). Virtually all respondents were supportive of somatic editing in basic-science (99.2%) and clinical (87.4%) research on nonreproductive human cells. Only 57.2% were supportive of germline-editing basic-science research; 31.9% supported the transfer of viable embryos to humans for clinical research. While most favored future therapeutic uses of somatic (96.6%) and germline (77.8%) editing, there was little support for enhancement in somatic (13.0%) or germline (8.6%) cells. This study describes attitudes toward gene editing from genetics professionals worldwide and contributes to ongoing discourse and policy guidance in this domain.