In Vitro Antimicrobial Activity of Thymus vulgaris Essential Oil Against Major Oral Pathogens.
In Vitro Antimicrobial Activity of Thymus vulgaris Essential Oil Against Major Oral Pathogens.
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DOI：
10.1177/2156587217700772
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发表时间：
2017-10
期刊：
影响因子：
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通讯作者：
Kohanteb J
中科院分区：
文献类型：
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作者：
Fani M;Kohanteb J
目的：研究百里香油对口腔致病菌的抑菌作用。采用水蒸气蒸馏法制备百里香油，用琼脂纸片扩散法和肉汤微量稀释法分别对30株临床分离的化脓性链球菌、变形链球菌、白色念珠菌、牙龈卟啉单胞菌和伴生放线杆菌进行检测。琼脂纸片扩散法测得，16~2 5 6μg/m L的百里香油对所有临床分离株均有较强的抑制作用，抑菌区间为7.5~42 mm。最敏感的菌株为化脓性链球菌和变形链球菌，最低抑菌浓度分别为1.9g/m L和3.6g/μ。对白色念珠菌、伴生放线菌和牙龈假单胞菌的最低抑菌浓度分别为16.3、32和32μg/m L。
The objective of present investigation was to determine antimicrobial activity of Thymus vulgaris oil on some oral pathogens. Thymus vulgaris oil was prepared by hydrodistillation and tested against 30 clinical isolates of each of Streptococcus pyogenes, Streptococcus mutans, Candida albicans, Porphyromonas gingivalis, and Aggregatibacter actinomycetemcomitans, prepared from related oral infections using agar disk diffusion and broth microdilution methods. Thymus vulgaris oil at concentrations of 16 to 256 μg/mL exhibited strong inhibitory activity on all clinical isolates producing inhibition zones of 7.5 to 42 mm as measured by agar disk diffusion method. Streptococcus pyogenes and Streptococcus mutans were the most sensitive isolates with minimum inhibitory concentrations of 1.9 and 3.6 μg/mL, respectively. The minimum inhibitory concentration values for C albicans, A actinomycetemcomitans, and P gingivalis were 16.3, 32, and 32 μg/mL, respectively.