IDENTIFICATION OF THE MIDBRAIN LOCOMOTOR REGION AND ITS RELATION TO DESCENDING LOCOMOTOR PATHWAYS IN THE ATLANTIC STINGRAY, DASYATIS-SABINA
IDENTIFICATION OF THE MIDBRAIN LOCOMOTOR REGION AND ITS RELATION TO DESCENDING LOCOMOTOR PATHWAYS IN THE ATLANTIC STINGRAY, DASYATIS-SABINA
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DOI：
10.1016/0006-8993(91)90119-g
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发表时间：
1991-08-23
期刊：
影响因子：
2.9
通讯作者：
LEONARD, RB
中科院分区：
文献类型：
--
作者：
BERNAU, NA;PUZDROWSKI, RL;LEONARD, RB
本文报道了大西洋黄貂鱼中脑运动区（MLR）的结构特征。 刺激（50-100 μ A，60 Hz）的中脑去大脑，瘫痪的动物被用来引发运动监测为交替活动的神经支配的拮抗剂对升降肌和降压肌。 有效的网站唤起运动在中脑包括几个核的部分：尾侧部分的中间核的内侧纵束和尾内侧部分的楔状核和楔下核。 该区域不包括红核、视顶盖的任何部分或中脑内侧核或外侧核。 在MLR电刺激引起运动在同侧或对侧胸鳍，而刺激在延髓网状结构引起运动只在对侧鳍。 进行损伤实验以确定从中脑到延髓网状结构的下行通路的位置。 要取消运动引起的电刺激在MLR，内侧网状结构在延髓的喙部被损坏的双边，或同侧的内侧延髓网状结构和纤维从MLR到对侧中脑的投射被破坏。 大细胞/巨细胞网状结构的HRP注射证实，该地区收到双边的预测从MLR。 大西洋黄貂鱼的MLR似乎类似于哺乳动物MLR的横向分量和其他非哺乳类脊椎动物的MLR。
The midbrain locomotor region (MLR) in the Atlantic stingray, Dasyatis sabina, was identified and characterized. Stimulation (50-100-mu-A, 60 Hz) of the midbrain in decerebrated, paralyzed animals was used to elicit locomotion monitored as alternating activity in nerves innervating an antagonist pair of elevator and depressor muscles. Effective sites for evoking locomotion in the midbrain included parts of several nuclei: the caudal portion of the interstitial nucleus of the medial longitudinal fasciculus and the caudomedial parts of the cuneiform and subcuneiform nuclei. This region did not include the red nucleus, any parts of the optic tectum or the medial or lateral mesencephalic nuclei. Electrical stimulation in the MLR evokes locomotion in either the ipsi- or contralateral pectoral fin, whereas stimulation in the medullary reticular formation evokes locomotion only in the contralateral fin. Lesion experiments were performed to identify the location of descending pathways from the midbrain to the medullary reticular formation. To abolish locomotion evoked by electrical stimulation in the MLR, the medial reticular formation in the rostral medulla had to be lesioned bilaterally, or the ipsilateral medial medullary reticular formation and fibers projecting from the MLR to the contralateral midbrain had to be disrupted. Injections of HRP into the magnocellular/gigantocellular reticular formation confirmed that this area received bilateral projections from the MLR. The MLR of the Atlantic stingray appears to be similar to the lateral component of the mammalian MLR and to the MLR in other non-mammalian vertebrates.